Microfluidic Chip Coupled with Thermal Desorption Atmospheric Pressure Ionization Mass Spectrometry

• Chang Chia-Hsien

  Department of Applied Chemistry, National Chiao Tung University

• Chen Tsung-Yi

  Department of Applied Chemistry, National Chiao Tung University

• Chen Yu-Chie

  Department of Applied Chemistry, National Chiao Tung University

抄録

Microfluidic chips have been used as platforms for a diversity of research purposes such as for separation and micro-reaction. One of the suitable detectors for microfluidic chip is mass spectrometry. Because microfluidic chips are generally operated in an open air condition, mass spectrometry coupled with atmospheric pressure ion sources can suit the requirement with minimum compromise. In this study, we develop a new interface to couple a microfluidic chip with mass spectrometry. A capillary tip coated with a layer of graphite, capable of absorbing energy of near-infrared (NIR) light is used to interface microfluidic chip with mass spectrometry. An NIR laser diode (λ=808 nm) is used to irradiate the capillary tip for assisting the generation of spray from the eluent of the microfluidic chip. An electrospray is provided to fuse with the spray generated from the microfluidic chip for post-ionization. Transesterification is used as the example to demonstrate the feasibility of using this interface to couple microfluidic chip with mass spectrometry.

収録刊行物

• Mass Spectrometry

  Mass Spectrometry 3 (Special_Issue), S0026-S0026, 2014

  一般社団法人　日本質量分析学会

キーワード

• mass spectrometry
• atmospheric pressure ionization
• thermal desorption
• microfluidic chip
• transesterification
• graphite

詳細情報

• CRID: 1390001205416239104
• NII論文ID: 130004727170
• DOI: 10.5702/massspectrometry.s0026
• ISSN: 21865116
• ISSN: 2187137X
• Web Site: https://www.jstage.jst.go.jp/article/massspectrometry/3/Special_Issue/3_S0026/_pdf
• 本文言語コード: en
• データソース種別:
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  • Crossref
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• 抄録ライセンスフラグ: 使用不可