Current view of the potential roles of proteins enriched on the inactive X chromosome

• Nakajima Tatsuro

  Graduate School of Medical Sciences, Kyushu University

• Sado Takashi

  Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University

抄録

X chromosome inactivation (X-inactivation) is triggered by X-linked noncoding Xist RNA, which is expressed asymmetrically from one of the two X chromosomes in females and coats it in cis to induce chromosome-wide silencing. Xist RNA is thought to play a role as a platform in recruiting proteins involved in gene silencing and heterochromatinization, which mediate serial changes in epigenetic modification of the chromatin. During the last two decades, many proteins have been shown to be enriched on the inactivated X chromosome in mouse and human. Although the biological significance of most of them for X-inactivation has not been fully established, extensive studies of these proteins should provide a better understanding of the molecular basis of how X-inactivation mediated by Xist RNA is regulated. Here, we review the potential roles of some of these proteins in the stepwise process of Xist RNA-mediated chromosome silencing.

収録刊行物

• Genes & Genetic Systems

  Genes & Genetic Systems 89 (4), 151-157, 2014

  日本遺伝学会

キーワード

• epigenetic regulation
• gene silencing
• heterochromatin
• X chromosome
• <i>Xist</i> RNA

詳細情報

• CRID: 1390282680450710016
• NII論文ID: 130004750052
• NII書誌ID: AA11077421
• DOI: 10.1266/ggs.89.151
• ISSN: 18805779
• ISSN: 13417568
• NDL書誌ID: 026154960
• PubMed: 25747039
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026154960
• Web Site: https://search.jamas.or.jp/link/ui/2016128428
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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