出芽酵母のメンブレントラフィックにおけるRab GTPaseネットワーク

• 長野 真

  東京理科大学総合研究機構RNA科学研究センター

• 十島 純子

  東京理科大学総合研究機構RNA科学研究センター 早稲田大学理工学術院創造理工学部

• 十島 二朗

  東京理科大学総合研究機構RNA科学研究センター 東京理科大学基礎工学部生物工学科

書誌事項

タイトル別名

• Rab GTPases Networks in Membrane Traffic in <i>Saccharomyces cerevisiae</i>
• シュツガ コウボ ノ メンブレントラフィック ニ オケル Rab GTPase ネットワーク

抄録

  Intracellular membrane trafficking between membranous compartments is essential for organelle biogenesis, structure, and identity. Rab/Ypt GTPases are well-characterized regulators of intracellular membrane trafficking, functioning as molecular switches that alternate between GTP- and GDP-bound forms. In Saccharomyces cerevisiae, 11 Rab/Ypt GTPases have been identified and their functions are known to be conserved in their mammalian counterparts. In yeast, the secretory pathway is regulated by sequential activation and inactivation (the so-called Rab cascade) of three types of yeast Rab protein -Ypt1p, Ypt31p/32p and Sec4p -via specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). In addition to these Rabs, we and others have recently demonstrated that Ypt6p is predominantly localized to the early Golgi compartment, and functions as another regulator of anterograde transport for intra-Golgi trafficking in the secretory pathway. On the other hand, the endocytic pathway is known to be regulated by three yeast Rab5s (Vps21p, Ypt52p and Ypt53p) and one Rab7 (Ypt7p). Rab5 and Rab7 are key determinants of endosome identity, and the Rab5-Rab7 cascade is important for the progression from early to late endosome. Our recent study demonstrates that the endocytic pathway branches into two vacuolar targeting pathways, the Rab5-dependent vacuole protein sorting (VPS) pathway and the Rab5-independent pathway. In this review, we focus on recent advances in our understanding of molecular mechanisms that regulate the localization and activity of yeast Rab GTPases in intracellular membrane trafficking.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 135 (3), 483-492, 2015-03-01

  公益社団法人 日本薬学会

キーワード

• Rab/Ypt GTPase
• membrane traffic
• Rab5
• budding yeast

詳細情報

• CRID: 1390282681106268672
• NII論文ID: 130004756514
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.14-00246
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 026197203
• PubMed: 25759056
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026197203
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/135/3/135_14-00246/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015185142
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可