Attainment of glycaemic goals by step-up therapy with biphasic insulin aspart-70/30 in Japanese type 2 diabetic patients

DOI Web Site 参考文献11件
  • Hosoi Yasuhiro
    Department of Internal Medicine, Isesaki Municipal Hospital, Isesaki, Japan
  • Ohtani Ken-Ichi
    Department of Internal Medicine, Isesaki Municipal Hospital, Isesaki, Japan
  • Shimizu Hiroyuki
    Faculty of Health Care, Kiryu University, Midori, Japan
  • Kashima Kouji
    Department of Internal Medicine, Kiryu Kosei General Hospital, Kiryu, Japan
  • Sato Noriyuki
    Sato Clinic, Gunma, Japan
  • Akiyama Hitoshi
    Department of Internal Medicine, Toho Hospital, Midori, Japan
  • Mori Masatomo
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan

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抄録

We have made step-up titration protocol with biphasic insulin aspart-70/30 (BIAsp 30), and tried to achieve glycemic goals in poorly controlled Japanese type 2 diabetic patients. We summarized all results obtained to analyze the effectiveness of our protocol. The target of glycaemic control was defined as HbA1c over 7.0 %. In our insulin initiation protocol, all patients started a once-daily injection of BIAsp 30 before the breakfast in addition to their oral hypoglycaemic agents. The patients who could not achieve the target from 12 to 16 weeks after the start of insulin treatment proceeded to twice daily insulin injection before breakfast and dinner. Next, the patients who could not achieve the target from 12 to 16 weeks after the addition of another BIAsp injection proceeded to thrice daily insulin injection before each meal a day. The results of 39 patients were analyzed, and 10.3 % of all patients achieved the target after the start of once daily injection of BIAsp 30, 41.7 % achieved in twice daily injection of BIAsp, and 51.4 % achieved in thrice daily injection of BIAsp. Daily insulin dose at the end of each treatment was 9.3±4.1 U in once daily, 17.4±6.3 U in twice daily, and 28.4±10.4 U in thrice daily. Total body weight increase by 2.0±2.6 kg. The initiation and titration protocol with BIAsp 30 improved glycaemic control, and increased the number of patients with the achievement of glycaemic goals.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 58 (2), 131-135, 2011

    一般社団法人 日本内分泌学会

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