Low bone mineral density is associated with dyslipidemia in South Korean men: The 2008–2010 Korean National Health and Nutrition Examination Survey
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- Kim Yang-Hyun
- Department of Family Medicine, Korea University College of Medicine, Seoul, Korea
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- Nam Ga-Eun
- Department of Family Medicine, Korea University College of Medicine, Seoul, Korea
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- Cho Kyung-Hwan
- Department of Family Medicine, Korea University College of Medicine, Seoul, Korea
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- Choi Youn Seon
- Department of Family Medicine, Korea University College of Medicine, Seoul, Korea
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- Kim Seon-Mee
- Department of Family Medicine, Korea University College of Medicine, Seoul, Korea
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- Han Byung-Duck
- Department of Family Medicine, Korea University College of Medicine, Seoul, Korea
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- Han Kyung Do
- Department of Medical Statistics, Catholic University College of Medicine, Seoul, Korea
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- Lee Kyung-Shik
- Department of Family Medicine, Wonkwang University Sanbon Hospital, Sanbon, Korea
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- Park Chang-Hae
- Department of Family Medicine, Eulji University Hospital, Daejeon, Korea
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- Kim Do-Hoon
- Department of Family Medicine, Korea University College of Medicine, Seoul, Korea
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This study examined the relationship between bone mineral density (BMD) and dyslipidemia in South Korean men. Data from 6,300 men who participated in the Korean National Health and Nutrition Examination Survey from 2008 to 2010 were analyzed, including serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) after 8 hours of fasting and mean BMD measured at the lumbar spine (LS), total hip (TH), and femoral neck (FN). Dyslipidemia was defined according to the criteria of the National Cholesterol Education Program Adult Treatment Panel ΙΙΙ. Other parameters of dyslipidemia were also calculated, such as TG/HDL-C, TC/HDL-C, non–HDL-C (NHDL-C), and LDL-C/HDL-C. Men with dyslipidemia and high levels of TG, TG/HDL-C, TC/HDL-C, NHDL-C, and LDL-C/HDL-C had lower BMD than men without dyslipidemia at the LS, TH, and FN after adjustment for age and body mass index (all p<0.01). On multivariable regression analysis, all odds ratios for high levels of TG, TG/HDL-C, TC/HDL-C, NHDL-C, and LDL-C/HDL-C with an increase in BMD (per standard deviation) were <1 at all 3 sites after adjustment for age and body mass index (model 1). After adjustment for all covariates, only odds ratios for high levels of TG, TG/HDL-C, TC/HDL-C, and NHDL-C were <1 at all 3 sites (model 2), but an increase in BMD was not associated with high LDL-C levels in models 1 and 2. In conclusion, BMD was inversely correlated with parameters of atherogenic dyslipidemia in South Korean men.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 60 (10), 1179-1189, 2013
一般社団法人 日本内分泌学会
