Analysis and Antibacterial Activity of Nigella sativa Essential Oil Formulated in Microemulsion System
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- Shaaban Hamdy A.
- Aroma & Flavor Chemistry Department, National Research Center
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- Sadek Zainab
- Dairy Department, National Research Center
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- Edris Amr E.
- Aroma & Flavor Chemistry Department, National Research Center
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- Saad-Hussein Amal
- Environmental & Occupational Medicine Department National Research Center
書誌事項
- タイトル別名
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- Analysis and Antibacterial Activity of <i>Nigella sativa</i> Essential Oil Formulated in Microemulsion System
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The Essential oil (EO) of Nigella sativa (black cumin) was extracted from the crude oil and the volatile constituents were characterized using gas chromatographic analysis. The EO was formulated in water-based microemulsion system and its antibacterial activity against six pathogenic bacteria was evaluated using the agar well diffusion method. This activity was compared with two other well known biologically active natural and synthetic antimicrobials namely eugenol and Ceftriaxone®. Results showed that N. sativa EO microemulsion was highly effective against S. aureus, B. cereus and S. typhimurium even at the lowest tested concentration of that EO in the microemulsion (100.0 μg/well). Interestingly, the EO microemulsion showed higher antibacterial activity than Ceftriaxone solution against S. typhimurium at 400.0 μg/well and almost comparable activity against E. coli at 500.0 μg/well. No activity was detected for the EO microemulsion against L. monocytogenes and P. aeruginosa. Eugenol which was also formulated in microemulsion was less effective than N. sativa EO microemulsion except against P. aeruginosa. The synthetic antibiotic (Ceftriaxone) was effective against most of the six tested bacterial strains. This work is the first report revealing the formulation of N. sativa EO in microemulsion system and investigating its antibacterial activity. The results may offer potential application of that water-based microemulsion in controlling the prevalence of some pathogenic bacteria.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 64 (2), 223-232, 2015
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679067386624
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- NII論文ID
- 130004800099
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 026060054
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- PubMed
- 25748382
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可