Pulmonary findings without the influence of therapy in a patient with rheumatoid arthritis: an autopsy case

• Hashimoto Kiyoshi

  Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University

• Nakanishi Hirofumi

  Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University

• Yamasaki Akira

  Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University

• Chikumi Hiroki

  Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University

• Hasegawa Yasuyuki

  Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University

• Watanabe Masanari

  Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University

• Ito Hisao

  Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University

• Shimizu Eiji

  Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University

抄録

We report the autopsy findings of a 40- year- old woman with lung complications of rheumatoid arthritis. She has been suffering from rheumatoid arthritis and interstitial pneumonia without satisfactory therapies because of her poor compliance. At autopsy, diffuse pleural adhesions and many protruding cysts were observed. The cut surfaces had rich fibrous changes and honey-comb like appearances dominantly in the left lower lobe. Microscopically, remarkable fibrous changes were observed with destruction of the alveolar structure. These fibroses were temporally homogeneous and lacked prominent fibroblastic foci. The histological pattern was consistent with fibrous non- specific interstitial pneumonia. In peripheral pulmonary arterioles, some thrombi were detected with much recanalization. Systemic amyloidosis was observed in the submandibular gland, thyroid, heart, and arterioles of the lung, kidney, and digestive tract. In the left pulmonary artery, a large embolus was detected. This embolism was the direct cause of death. Her pulmonary findings, except for the embolism, were considered sober states of lung complications of rheumatoid arthritis without the influence of therapy. J. Med. Invest. 54: 340-344, August, 2007

収録刊行物

• The Journal of Medical Investigation

  The Journal of Medical Investigation 54 (3,4), 340-344, 2007

  国立大学法人　徳島大学医学部

キーワード

• pulmonary findings
• rheumatoid arthritis
• interstitial pneumonia
• autopsy

詳細情報

• CRID: 1390282679219607808
• NII論文ID: 130004822557
• NII論文ID: 80018233524
• NII書誌ID: AA11166929
• DOI: 10.2152/jmi.54.340
• ISSN: 13496867
• ISSN: 13431420
• Web Site: http://repo.lib.tokushima-u.ac.jp/111538
• Web Site: http://www.jstage.jst.go.jp/article/jmi/54/3,4/54_3,4_340/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008142027
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可