In vitro biocompatibility of Ni-free Ti-based shape memory alloys for biomedical applications
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- Kanetaka Hiroyasu
- Department of Physical Medicine and Rehabilitation, Graduate School of Biomedical Engineering, Tohoku University Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University
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- Hosoda Hideki
- Precision and Intelligence Laboratory, Tokyo Institute of Technology
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- Shimizu Yoshinaka
- Division of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University
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- Kudo Tada-aki
- Division of Oral Physiology, Graduate School of Dentistry, Tohoku University
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- Zhang Ye
- Department of Physical Medicine and Rehabilitation, Graduate School of Biomedical Engineering, Tohoku University
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- Kano Mitsuhiro
- Division of Oral and Craniofacial Anatomy, Graduate School of Dentistry, Tohoku University
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- Sano Yuya
- Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University
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- Miyazaki Shuichi
- Institute of Materials Science, University of Tsukuba
書誌事項
- タイトル別名
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- <I>In Vitro</I> Biocompatibility of Ni-Free Ti-Based Shape Memory Alloys for Biomedical Applications
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This study was undertaken to evaluate the in vitro biocompatibility of newly developed Ni-free Ti-based shape memory alloys (SMAs) in comparison to that of commercial pure titanium (cpTi). This study compared Ti-24 mol%Nb-3 mol%Al (Ti-Nb-Al) and Ti-7 mol%Cr-3 mol%Sn (Ti-Cr-Sn) to cpTi from a cell-compatibility perspective. In all, 63 samples (21 samples for each group) were prepared, which were machined into 10-mm-diameter, 0.15-mm-thick, mirror-polished disks. Their surface morphology was evaluated using scanning electron microscopy (SEM). The chemical composition of the sample surface was determined using an energy dispersive X-ray analyzer (EDX). Sample surface roughness was measured using a non-contact 3D profiler. After sample surface observations, the cell proliferation and viability of African green monkey kidney fibroblast cell line COS7 in direct contact with these new alloys were evaluated by DNA quantification, by live cell imaging using CelLuminate Red fluorescent cell stain as a new method, and by cytoskeletal observations by immunofluorescent actin labelling. Cell proliferation was examined after 1, 3, and 5 days of culture. Results were the following. (i) Each sample showed high purity and a very smooth surface, showing no morphological differences among groups. (ii) The COS7 cells took in sufficient CelLuminate Red to visualize the cells using epifluorescent microscopy, and (iii) cell proliferation with Ti-Cr-Sn was lower than with either cpTi or Ti-Nb-Al. These results suggest that Ti-Nb-Al alloy showed biocompatibility as high as that of cpTi and that it is more suitable for biomedical applications.
収録刊行物
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- MATERIALS TRANSACTIONS
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MATERIALS TRANSACTIONS 51 (10), 1944-1950, 2010
公益社団法人 日本金属学会
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詳細情報 詳細情報について
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- CRID
- 1390001204249567104
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- NII論文ID
- 10026695718
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- NII書誌ID
- AA1151294X
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- ISSN
- 13475320
- 13459678
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- NDL書誌ID
- 10831907
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可