書誌事項
- タイトル別名
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- Clinical Results of Systemic Chemotherapy Combined with Regional Hyperthermia
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Hyperthermia (HT) can be directly cytotoxic to cancer cells, and can also act as a radiation-sensitizer and chemo-sensitizer. Although the combination of HT with radiotherapy has been the primary focus for research, there is an equally strong rationale for combining HT with chemotherapy (CT). New chemotherapeutic agents, such as irinotecan, oxaliplatin, gemcitabine and taxane, have been demonstrated to show thermal enhancement in several in vitro and/or in vivo studies.<BR> With regional or local HT, drug- and heat-induced toxicity can be localized, and systemic toxicity can be avoided or minimized. Generally, regional HT is less invasive than interstitial or intracavitary local HT, and can enhance chemotherapeutic effects in specific sites in the body. In many instances, systemic CT represents the most useful option for patients with surgically incurable malignant neoplasms. An approach which combines systemic CT with regional HT should be of interest, since it can enhance the efficacy of systemic chemotherapeutic drugs in specific areas. Here, we review clinical results of systemic CT combined with regional HT for the treatment of malignant neoplasms.
収録刊行物
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- 日本ハイパーサーミア学会誌
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日本ハイパーサーミア学会誌 23 (2), 49-61, 2007
日本ハイパーサーミア学会
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詳細情報 詳細情報について
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- CRID
- 1390282679329273728
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- NII論文ID
- 10029676762
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- NII書誌ID
- AN10084762
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- ISSN
- 18822576
- 18819516
- 09112529
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- NDL書誌ID
- 9267102
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可