Regions of Arterial Stenosis and Clinical Factors Determining Transcutaneous Oxygen Tension in Patients with Peripheral Arterial Disease

• Ueno Hiroki

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Fukumoto Shinya

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Koyama Hidenori

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Tanaka Shinji

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Maeno Takaaki

  Internal Medicine, Minami Osaka General Hospital.

• Murayama Masahiro

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Otsuka Yoshiko

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Mima Yohei

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Kawaguchi Yuji

  Internal Medicine, Minami Osaka General Hospital.

• Shoji Tetsuo

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Inaba Masaaki

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

• Nishizawa Yoshiki

  Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.

抄録

Aims: Despite the clinical usefulness of transcutaneous oxygen tension (TcPO₂) to assess the severity of limb ischemia, the factors determining TcPO₂ in patients with peripheral arterial disease (PAD) have not been fully clarified. We therefore examined the regions of arterial stenosis and clinical factors affecting lower-extremity TcPO₂.<BR>Methods: Resting TcPO₂ (REST-TcPO₂) and postexercise TcPO₂ (Ex-TcPO₂) in the calf region and the dorsalis pedis were measured simultaneously in 66 patients (132 limbs) with clinically suspected PAD, in whom angiography was also performed.<BR>Results: The peripheral arteries of the lower extremities were divided into five segments, and the impact of significant stenosis in each segment on ipsilateral TcPO₂ was evaluated by multiple regression analysis. In the calf region, significant stenosis of the proximal arteries (common-external iliac artery) revealed stronger involvement determining Ex-TcPO₂ than the peripheral segment (posterior tibial artery). In the dorsalis pedis, the peripheral segment (anterior tibial artery) more strongly determined Ex-TcPO₂ and REST-TcPO₂ than proximal segments. Age, creatinine, and diabetes were associated with REST-TcPO₂ of the calf region independent of arterial stenoses, while those of the dorsalis pedis were independently associated with age, and creatinine. In contrast, Ex-TcPO₂ in both regions was not independently associated with clinical factors, except for stenosis of the perfusing arteries.<BR>Conclusion: The vascular lesions affecting TcPO₂ differ between the calf region (proximal > peripheral) and the dorsalis pedis (proximal < peripheral). In addition postexercise TcPO₂ is solely determined by stenosis of the perfusing arteries, while TcPO₂ at rest is affected by multiple clinical factors.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 17 (8), 858-869, 2010

  一般社団法人 日本動脈硬化学会

キーワード

• TcPO₂
• Angiography
• PAD
• Diabetes mellitus
• CKD

詳細情報

• CRID: 1390001204431463808
• NII論文ID: 130004845336
• DOI: 10.5551/jat.3723
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://search.jamas.or.jp/link/ui/2011131782
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可