Clinical Impact of the Leptin to Soluble Leptin Receptor Ratio on Subclinical Carotid Atherosclerosis in Patients with Type 2 Diabetes
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- Yamazaki Yuko
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Emoto Masanori
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Morioka Tomoaki
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Kawano Naoya
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Lee Eiko
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Urata Hiromi
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Tsuchikura Shoko
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Motoyama Koka
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Mori Katsuhito
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Fukumoto Shinya
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Shoji Tetsuo
- Department of Geriatrics and Vascular Medicine, Osaka City University Graduate School of Medicine.
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- Nishizawa Yoshiki
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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- Inaba Masaaki
- Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
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Aim: The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin and the soluble leptin receptor (sOb-R) with atherosclerosis in patients with type 2 diabetes.<BR>Methods: Three hundred seventeen type 2 diabetic subjects were enrolled in this cross-sectional study. Fasting plasma leptin and sOb-R concentrations were measured by enzyme-linked immunosorbent assays. The intima-media thickness (IMT) of the common carotid artery was measured by ultrasound.<BR>Results: The IMT was significantly associated with sOb-R concentrations, age, diabetes duration, serum creatinine (sCre) levels, and systolic blood pressure (SBP), but not with leptin concentrations or the leptin/sOb-R ratio. The concentrations of leptin (r=0.478, p<0.001) and the sOb-R (r= −0.404, p<0.001) and the leptin/sOb-R ratio (r=0.501, p<0.001) were strongly correlated with IMT in subjects treated with insulin for glycemic control, but not in those treated with diet alone or oral hypoglycemic agents. Multiple regression analysis, including age, sex, diabetes duration, body mass index, SBP, HbA1c, triglycerides, LDL-cholesterol, sCre, smoking, and insulin therapy, revealed that plasma leptin and the leptin/sOb-R ratio were independently associated with IMT in subjects treated with insulin.<BR>Conclusions: Plasma leptin and the leptin/sOb-R ratio are associated with atherosclerosis in patients with type 2 diabetes on insulin therapy, and these associations were independent of obesity and other cardiovascular risk factors.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 20 (2), 186-194, 2013
一般社団法人 日本動脈硬化学会
