Results from 28 Years of Newborn Screening for Congenital Adrenal Hyperplasia in Sapporo
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- Morikawa Shuntaro
- Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
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- Nakamura Akie
- Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
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- Fujikura Kaori
- Sapporo City Institute of Public Health, Sapporo, Japan
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- Fukushi Masaru
- Sapporo Immunodiagnostic Laboratory, Sapporo, Japan
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- Hotsubo Tomoyuki
- Department of Pediatrics, NTT East Japan Sapporo Hospital, Sapporo, Japan
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- Miyata Jun
- Sapporo City Institute of Public Health, Sapporo, Japan
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- Ishizu Katsura
- Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
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- Tajima Toshihiro
- Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
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抄録
The primary goal of newborn mass screening (MS) for congenital adrenal hyperplasia (CAH) is the prevention of life-threatening salt-wasting crisis in the most severe forms of CAH, and MS for CAH has been implemented in several countries. We summarize here our experience and results from newborn CAH MS from 1982 to 2010 in Sapporo City. During these 28 yr, the level of 17-hydroxyprogesterone (17-OHP) was determined in MS of samples from 498,147 newborns. During this period, 26 individuals (19 females and 7 males) with 21-hydroxylase deficiency (21-OHD) were detected. Of the 26 CAH, 20 were classified as having the salt-wasting (SW) form, 4 were classified as having the simple virilizing (SV) form, and 2 were classified as having the noncalssic (NC) form. Therefore, the frequency of the classical type of CAH was 1 in 20,756. In order to improve the effectiveness, we employed high-performance liquid chromatography (HPLC) as a second tier test from 2000. During this period, among the recalled babies, 75.4% were born prior to the 37th wk of gestation age, and the recall rate was 5.38% for premature neonates and 0.06% for mature neonates. MS for CAH in Sapporo is effective for the identification of the SW and SV forms of 21-OHD. However, the recall rate of premature babies is still high after the introduction of HPLC as a second tier test.
収録刊行物
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- Ｃｌｉｎｉｃａｌ Ｐｅｄｉａｔｒｉｃ Ｅｎｄｏｃｒｉｎｏｌｏｇｙ
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Ｃｌｉｎｉｃａｌ Ｐｅｄｉａｔｒｉｃ Ｅｎｄｏｃｒｉｎｏｌｏｇｙ 23 (2), 35-43, 2014
日本小児内分泌学会
