Attenuation by Oren-gedoku-to Extract (TJ-15) of Disruption of Hepatic Reactive Oxygen Species Metabolism with Progression of Carbon Tetrachloride-Induced Acute Liver Injury in Rats
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- Ohta Yoshiji
- Department of Chemistry, School of Medicine, Fujita Health University
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- Kongo-Nishimura Mutsumi
- Department of Pediatric Surgery, School of Medicine, Fujita Health University
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- Hayashi Takahiro
- Department of Pharmacy, Fujita Health University Hospital
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- Matsura Tatsuya
- Division of Medical Biochemistry, Department of Pathophysiology and Therapeutic Science, Faculty of Medicine, Tottori University
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- Yamada Kazuo
- Division of Medical Biochemistry, Department of Pathophysiology and Therapeutic Science, Faculty of Medicine, Tottori University
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We attempted to elucidate how Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract (TJ-15), a Chinese herbal medicine, attenuates the disruption of hepatic reactive oxygen species metabolism with the progression of carbon tetrachloride (CCl4)-induced acute liver injury in rats. TJ-15 (100, 250 or 500 mg/kg body weight) was orally administered to rats injected with CCl4 (1 ml/kg, i.p.) at 6 h after the toxicant treatment. Post-administered TJ-15 reduced progressive liver injury in CCl4-treated rats at 24 h after the toxicant treatment dose-dependently. The liver of rats treated with CCl4 alone showed increases in the concentration of thiobarbituric acid-reactive substances, an index of lipid peroxidation, and xanthine oxidase activity and decreases in reduced glutathione and ascorbic acid concentrations and superoxide dismutase, catalase, and glutathione reductase activities at 24 h after the toxicant treatment. The liver of CCl4-treated rats showed no change in Se-glutathione peroxidase activity and an increase in hepatic glucose-6-phosphate dehydrogenase activity at 24 h after the toxicant treatment. Post-administered TJ-15 attenuated the increases in hepatic thiobarbituric acid-reactive substances and xanthine oxidase activity and the decreases in hepatic reduced glutathione and ascorbic acid concentrations and superoxide dismutase, catalase, and glutathione reductase activities dose-dependently but did not affect the hepatic Se-glutathione peroxidase activity and the increased hepatic glucose-6-phosphate dehydrogenase activity. These results indicate that orally administered TJ-15 attenuates the disruption of hepatic reactive oxygen species metabolism with the progression of CCl4-induced acute liver injury in rats through its direct and indirect antioxidant actions. The results also suggest that this attenuating effect of TJ-15 could contribute to its preventive effect on the progression of CCl4-induced acute liver injury.
収録刊行物
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 39 (3), 153-161, 2006
一般社団法人 日本酸化ストレス学会
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詳細情報 詳細情報について
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- CRID
- 1390001204672888704
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- NII論文ID
- 130004879101
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- ISSN
- 18805086
- 09120009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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