HPLC法によるクリノフィブレートの抗高脂血症作用の検討

J-STAGE
  • 田中 明
    Third Department of Internal Medicine, Tokyo Medical and Dental University
  • 高木 優美子
    Third Department of Internal Medicine, Tokyo Medical and Dental University
  • 藤沼 悦範
    Third Department of Internal Medicine, Tokyo Medical and Dental University
  • 中條 やえ子
    Third Department of Internal Medicine, Tokyo Medical and Dental University
  • 杉山 安彦
    Third Department of Internal Medicine, Tokyo Medical and Dental University
  • 若林 哲雄
    Third Department of Internal Medicine, Tokyo Medical and Dental University
  • 内村 功
    Third Department of Internal Medicine, Tokyo Medical and Dental University
  • 前沢 秀憲
    Third Department of Internal Medicine, Tokyo Medical and Dental University

書誌事項

タイトル別名
  • Study on the Antihyperlipidemic Effect of Clinofibrate by Using the HPLC Method

抄録

We investigated the antihyperlipidemic effect of clinofibrate by using the HPLC Method. Changes of HPLC lipoprotein pattern were studied before and after clinofibrate administration of 1, 200mg/ day for three months in 13 hyper lipidemic patients with serum total cholesterol (TC)>220mg/dl or triglyceride (TG)>200mg/dl.<br>Serum TC and TG levels significantly decreased, while no significant changes were observed in serum HDL cholesterol levels.<br>Patients with type IIb and IV hyper lipidemia showed a decrease of VLDL fruction without an increase of free glycerol and LDL fruction. The result suggests that the decrease of VLDL fruction may not be due to the increase of VLDL catabolism by lipoprotein lipase.<br>Patients with type ha hyper lipidemia showed a decrease in LDL cholesterol. The result domonstrates the direct action of clinofibrate on LDL.

収録刊行物

  • 動脈硬化

    動脈硬化 18 (11), 1061-1066, 1990

    Japan Atherosclerosis Society

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