肝臓リポ蛋白レセプター

J-STAGE
  • 中島 浩一郎
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 林 幸三
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 平田 康彦
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 大谷 博正
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 堂上 慎也
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 西尾 栄助
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 佐伯 正弦
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 久留島 仁
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 堀内 至
    First Department of Internal Medicine, Hiroshima University, School of Medicine
  • 梶山 梧朗
    First Department of Internal Medicine, Hiroshima University, School of Medicine

書誌事項

タイトル別名
  • Lipoprotein Receptors of Liver

抄録

We investigated the possibility of the existence of hepatic Chylomicron Remnant (CR) receptors with HepG2 cells. In HepG2 cells incubated with LPDS or LPDS+25 OH cholesterol for 24 hours, the binding and internalization of 125I-CR were inhibited about 79.0% and 78.8% respectively by the incubation with unlabelled CR. On the other hand, in HepG2 cells incubated with LPDS or LPDS+25 OH cholesterol for 24 hours, the binding and internalization of 125I-CR were inhibited about 80.8% and 52.7% respectively by the incubation with unlabelled LDL. In human fibroblasts incubated with LPDS or LPDS+25 OH cholesterol for 24 hours, the bining and internalization of 125I-CR were inhibited about 79.7-82.4% and 73.7-78.6% by the incubation with unlabelled CR or unlabelled LDL. These results suggest that HepG2 cells may have functional remnant receptors which are not regulated by cholesterol loading.

収録刊行物

  • 動脈硬化

    動脈硬化 19 (1), 35-38, 1991

    Japan Atherosclerosis Society

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