Mechanism of Compensatory Growth with Changing Levels of Dietary Lysine from Deficient to Sufficient in Pigs

• ISHIDA Aiko

  Animal Physiology and Nutrition Research Division, NARO, National Institute of Livestock and Grassland Science

• NAKASHIMA Kazuki

  Animal Physiology and Nutrition Research Division, NARO, National Institute of Livestock and Grassland Science

• KYOYA Takahito

  Animal Physiology and Nutrition Research Division, NARO, National Institute of Livestock and Grassland Science United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology

• KATSUMATA Masaya

  Animal Physiology and Nutrition Research Division, NARO, National Institute of Livestock and Grassland Science

抄録

This review describes our studies on compensatory growth, specifically the growth that occurs after dietary lysine deficiency is changed to sufficiency. We found that dietary lysine sufficiency induced compensatory growth in pigs after dietary lysine deficiency. We also showed that compensatory growth of pigs induced by dietary lysine sufficiency was partly attributed to greater N retention. In a rat model, both suppression of proteolysis and increased protein synthesis in skeletal muscle contributed to their compensatory growth with lysine sufficiency. Finally, our in vitro studies with cultured skeletal muscle cells revealed that the compensatory growth in these cells was induced by increased lysine levels in combination with the modulation of insulin-like growth factor-I and glucocorticoid levels. This suggested that compensatory growth in pigs and rats with lysine sufficiency was due to both increased serum lysine levels and changes in the levels of hormones involved in protein synthesis and degradation.

収録刊行物

• Japan Agricultural Research Quarterly: JARQ

  Japan Agricultural Research Quarterly: JARQ 49 (1), 23-28, 2015

  国立研究開発法人　国際農林水産業研究センター

キーワード

• C2C12
• pig
• rat

詳細情報

• CRID: 1390001204702348032
• NII論文ID: 130004886283
• DOI: 10.6090/jarq.49.23
• ISSN: 21858896
• ISSN: 00213551
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可