Design of Photo-triggered Nitric oxide (NO)-releasing Nanoparticle for Novel Photodynamic Therapy

• Nagasaki Yukio

  Faculty of Pure and Applied Sciences, University of Tsukuba

Bibliographic Information

Other Title

• がん光線力学療法を目指した光NO 発生ナノ粒子の設計

Abstract

Core-shell type nanoparticles containing 4-nitro-3-trifluoromethylphenyl units in the core were prepared and their phototriggered nitric oxide (NO)-generating ability was confirmed by the spin trapping method using an electron spin resonance and the Griess method. These nanoparticles were found to deliver exogenous NO into tumor cells in a photocontrolled manner and showed an NO-mediated antitumor effect, indicating the usability of this molecular system in NO-based tumor therapy

Journal

• Nippon Laser Igakkaishi

  Nippon Laser Igakkaishi 34 (2), 138-140, 2013

  Japan Society for Laser Surgery and Medicine

Keywords

• nitric oxide
• photo-triggered NO-releasing nanoparticles
• apoptosis
• nanomedicine
• drug delivery system

Details

• CRID: 1390001204767648768
• NII Article ID: 130004893574
• DOI: 10.2530/jslsm.34.138
• ISSN: 18811639
• ISSN: 02886200
• Web Site: https://search.jamas.or.jp/link/ui/2014150432
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed