Compatibility of Heparin Sodium in Intravenous Line with Nicardipine Injected from a Side Tube via T-shape Stopcock

• Hayashi Takafumi

  Laboratory of Pharmaceutical Sciences, Tohoku Pharmaceutical University

• Uwai Koji

  Department of Applied Chemistry, Muroran Institute of Technology

• Sasaki Eri

  Laboratory of Pharmaceutical Sciences, Tohoku Pharmaceutical University

• Sasaki Keisuke

  Laboratory of Pharmaceutical Sciences, Tohoku Pharmaceutical University

• Iwabuchi Yasushi

  Friend Pharmacy Ishinomaki

• Agatsuma Hitoshi

  Department of Pharmacy, Ishinomaki Red Cross Hospital

• Suzuki Tsuneyoshi

  Laboratory of Pharmaceutical Sciences, Tohoku Pharmaceutical University

書誌事項

タイトル別名

• Compatibility of Heparin Sodium in Intravenous Line with Nicardipine Injected from a Side Tube <i>via</i> T-shape Stopcock

抄録

The compatibility caused by injection of Nicarpine^® 10 mg / 10 mL (Nicarpine^®) from a side tube into an intravenous line infused with Replas^® 1 Injection (Replas^® 1) and Novo-Heparin^® 10,000 units / 10 mL for Injection (Novo-Heparin^®) was investigated. We observed a mixed solution of each constituent of Replas^® 1 and Novo-Heparin^® with Nicarpine^®, and measured the IR spectrum of the precipitate and the ¹H-NMR spectrum of a saturated solution of the mixture of heparin and nicardipine. Our findings suggested that the compatibility was caused by an intermolecular interaction between heparin and nicardipine when in a 1:2 ration via the formation of a salt between the sulfate group and/or the carboxylic group of heparin and the amino group of nicardipine.

収録刊行物

• 医療薬学

  医療薬学 38 (11), 679-687, 2012

  一般社団法人日本医療薬学会

キーワード

• heparin sodium
• nicardipine
• compatibility
• injection <i>via</i> T-shape stopcock
• infusion

詳細情報

• CRID: 1390282679752537856
• NII論文ID: 130004894789
• DOI: 10.5649/jjphcs.38.679
• ISSN: 18821499
• ISSN: 1346342X
• Web Site: https://search.jamas.or.jp/link/ui/2013160886
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可