Early capsaicin intervention for neurogenic bladder in a rat model of spinal cord injury

• THOMAS Catherine

  Department of Urology, University of Pittsburgh School of Medicine

• KIM Jang Hwan

  Department of Urology, University of Pittsburgh School of Medicine Department of Urology, Yonsei University College of Medicine

• TORIMOTO Kazumasa

  Department of Urology, University of Pittsburgh School of Medicine

• KWON Dong Deuk

  Department of Urology, University of Pittsburgh School of Medicine

• KIM Yong Tae

  Department of Urology, University of Pittsburgh School of Medicine

• TYAGI Pradeep

  Department of Urology, University of Pittsburgh School of Medicine

• YOSHIMURA Naoki

  Department of Urology, University of Pittsburgh School of Medicine

• CHANCELLOR Michael B.

  Department of Urology, University of Pittsburgh School of Medicine

抄録

We explored capsaicin pretreatment, prior to spinal trauma, as a method to prevent the development of neurogenic detrusor overactivity (NDO) and urethral-bladder dyssynergia reflex after spinal cord injury (SCI). In addition, the duration of effect of capsaicin therapy on NDO in a rat model of SCI was investigated. Two sets of experiments were performed on female Sprague Dawley rats transected at the T9-T10 spinal level. First, SCI rats received capsaicin (125 mg/kg s.q.) 3-4 days before and 4-5 days after SCI. Cystometrograms (CMG) was performed 4 weeks after injury. In the second set of experiments, serial CMG in the same SCI animal was performed after one time injection of capsaicin (125 mg/kg s.q.) 4 weeks after spinalization. There were no differences in intercontraction intervals, voiding efficiency, or voiding pressure between the capsaicin pretreated and control SCI rats. However, the number of uninhibited detrusor contractions decreased 4 weeks after injury. We found that a single dose of capsaicin suppressed uninhibited detrusor contractions for 34 days in the chronic SCI animals. Early therapy with capsaicin was able to prevent/reduce detrusor hyperreflexia in spinal cord injured animals 4 weeks after injury. Early vanilloid therapy may prevent development of urologic sequelae after SCI.

収録刊行物

• Biomedical Research

  Biomedical Research 28 (5), 255-259, 2007

  バイオメディカルリサーチプレス

キーワード

• General Biochemistry, Genetics and Molecular Biology
• General Medicine

詳細情報

• CRID: 1390282679879680512
• NII論文ID: 130004903739
• DOI: 10.2220/biomedres.28.255
• ISSN: 1880313X
• ISSN: 03886107
• Web Site: https://search.jamas.or.jp/link/ui/2008115916
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可