Transformation of breast milk macrophages by HTLV-I: implications for HTLV-I transmission via breastfeeding
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- Takeuchi Hodaka
- Department of Microbiology and Immunology, Nippon Medical School Department of Pediatrics, Nippon Medical School
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- Takahashi Megumi
- Department of Microbiology and Immunology, Nippon Medical School
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- Norose Yoshihiko
- Department of Microbiology and Immunology, Nippon Medical School
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- Takeshita Toshiyuki
- Department of Obstetrics and Gynecology, Nippon Medical School
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- Fukunaga Yoshitaka
- Department of Pediatrics, Nippon Medical School
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- Takahashi Hidemi
- Department of Microbiology and Immunology, Nippon Medical School
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抄録
Human T cell leukemia virus type I (HTLV-I), a causative agent of adult T-cell leukemia (ATL), is transmitted from mother to child predominantly by breastfeeding. The source of HTLV-I-infected cells in breast milk has been thought to be T cells, however, the majority of cells in breast milk are CD14+ macrophages but not CD3+ T lymphocytes, and no data are available regarding HTLV-I transmission through breast milk macrophages (BrMMφ). To explore the potential of BrMMφ as a possible source of infection in mother to child transmission (MTCT) of HTLV-I, an immortalized cell line (HTLV-BrMMφ) has been established from BrMMφ by infection with HTLV-I. HTLV-BrMMφ retained macrophage characteristics and did not express a complete dendritic cell (DC) phenotype; nevertheless, HTLV-BrMMφ efficiently promoted T cell proliferation in primary allogeneic mixed lymphocyte reaction (MLR) like DC. Moreover, HTLV-I infection could be transmitted from HTLV-BrMMφ to activated T cells in the peripheral blood. These findings suggested that BrMMφ might be an appropriate HTLV-I reservoir involved in MTCT transmission via breastfeeding.
収録刊行物
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- Biomedical Research
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Biomedical Research 31 (1), 53-61, 2010
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詳細情報 詳細情報について
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- CRID
- 1390001204903146880
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- NII論文ID
- 130004903783
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- ISSN
- 1880313X
- 03886107
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可