Neurobehavioral evaluation of mouse newborns exposed prenatally to low-dose bisphenol A
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- Nagao Tetsuji
- Laboratory of Developmental Biology, Department of Life Science, Kinki University
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- Kawachi Kota
- Laboratory of Developmental Biology, Department of Life Science, Kinki University
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- Kagawa Nao
- Laboratory of Developmental Biology, Department of Life Science, Kinki University
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- Komada Munekazu
- Department of Anatomy, Aichi Gakuin University
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Abstract
There have been few neurobehavioral toxicology studies on newborn animals. Thus, we developed a mouse newborn behavioral testing method for evaluating the risk of neurotoxicity of environmental toxicants, by means of determining the newborn’s motor activity applying the tare function of an analytical balance. Motor activities including crawling, pivoting, righting or tremors of mouse newborns were evaluated. Tremors of newborns of dams exposed to bisphenol A at 2, 20 or 200 µg/kg/day on days 5 through 18 of gestation were significantly increased when evaluated on postnatal day 1, as well as those of newborns exposed prenatally to diethylstilbestrol at 0.5 µg/kg/day. We suggest that our developed testing method may provide a useful addition to neurobehavioral assessment in very young rodents exposed to environmental hormone mimics.
Journal
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 39 (2), 231-235, 2014
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390001204905651712
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- NII Article ID
- 130004903983
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- NII Book ID
- AN00002808
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- COI
- 1:STN:280:DC%2BC2crltlCgsw%3D%3D
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- ISSN
- 18803989
- 03881350
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- NDL BIB ID
- 025456380
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- PubMed
- 24646703
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed