尿崩症をはじめとする視床下部・下垂体系内分泌異常を伴い全身に多彩な病像を呈したサルコイドージスの1症例

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  • A case of sarcoidosis involving multiple organs presnting hypothalamus-hypothysis system disturbance.

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A 23 year-old male was diagnosed as having sarcoidosis with multiple manifestations associated with endocrinological disturbances of the hypothalamus-hypothysis system.<br>At the onset of disease, Heerfordt syndrome was present, appetite loss, low grade fever and systemic superficial lymphadenopathy, and then symptoms of diabetes insipidus appeared. Chest roentogenogram showed bilateral hilar node and reticular shadows in the right upper zone. Ocular lesions included typical chorioretinitis, periphlebitis and uveitis.<br>Laboratory examinations revelaed panhypopituitarism to the exclusion of prolactin, and brain CT showed a suprascleral mass. Other tests suggested that liver, spleen, bone and heart were involved.<br>Treatment by corticosteroids resulted in inprovement of symptoms other than D. I. Chest X-ray and brain CT revealed that the abnormal shadows disappeared and laboratory examinations showed that the endocrinological disturbances gradually improved. Diabetes insipidus was well controlled by replacement therapy with vasopressin by nasal spray.

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