再生不良性貧血は単一疾患か症候群か

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書誌事項

タイトル別名
  • Is Aplastic Anemia a Clinical Entity or Syndrome?
  • サイセイ フリョウセイ ヒンケツ ワ タンイツ シッカン カ ショウコウグン

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抄録

It has been still controversial that idiopathic acquired aplastic anemia is a definite clinical entity.<br>Analysis of 51 cases with idiopathic aplastic anemia for the period of 12 years between 1962 and 1972 in the Keio University Hospital led us to conclude that aplastic anemia consists of two types: one is genuine (typical) aplastic anemia, the other aplastic anemia syndrome (atypical aplastic anemia). The diagnosis of genuine aplastic anemia should be made at the presence of pancytopenia with relative lymphocytosis, a-(hypo-)plastic bone marrow picture and elevated serum iron, One should make a diagnosis of aplastic anemia syndrome when found any two of following itemes: 1) reticulocytosis. 2) absence of relative lymphocytosis 3) monocytosis 4) erythroblasts in peripheral blood. 5) erythroid hyperplasia of bone marrow prior to treatment 6) left shift of myeloid series in bone marrow. 7) normal level of serum iron 8) splenomegaly.<br>Aplastic anemia syndrome can terminate in acute myelogenous leukemia, paroxysmal nocturnal hemoglobinemia (PNH) or aplastic anemia PNH syndrome. A part of the syndrome may be curable.<br>Thus genuine aplastic anemia is a definite clinical entity and should be strictly separated from aplastic anemia syndrome.

収録刊行物

  • 臨床血液

    臨床血液 14 (Suppl.), S1288-S1293, 1973

    一般社団法人 日本血液学会

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