Refractory Leg Ulcers Associated with Klinefelter Syndrome

  • Yabuno Yuto
    Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital
  • Tosa Mamiko
    Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital
  • Iwakiri Itaru
    Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital
  • Nomoto Shunichi
    Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital
  • Kaneko Mayuko
    Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital
  • Kuwahara Kousuke
    Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital
  • Hyakusoku Hiko
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School
  • Murakami Masahiro
    Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital

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抄録

We present a man with refractory leg ulcers, bilateral varicosis of the lower extremities, and Buerger disease. Autoimmune work-up was negative. However, chromosome analysis showed Klinefelter syndrome (48 XXY). Ulcerative lesions of the lower extremities are a complication of Klinefelter syndrome. To date, the pathogenesis of ulcers in Klinefelter syndrome has not been clarified, but several factors, such as abnormalities of fibrinolysis and prothrombotic states, might be involved. Our present case emphasizes the importance of considering Klinefelter syndrome in the differential diagnosis of a male patient with nonhealing ulcers of the lower extremities.

収録刊行物

  • 日医大誌

    日医大誌 82 (1), 64-67, 2015

    日本医科大学医学会

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