Renal Function and Peak Exercise Oxygen Consumption in Chronic Heart Failure With Reduced Left Ventricular Ejection Fraction
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- Scrutinio Domenico
- Division of Cardiology, “S. Maugeri” Foundation, IRCCS, Institute of Cassano Murge
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- Agostoni Piergiuseppe
- Centro Cardiologico Monzino, IRCCS Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano
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- Gesualdo Loreto
- Renal, Dialysis and Transplant Unit, Department of Emergency and Organ Transplantation, University of Bari
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- Corrà Ugo
- Division of Cardiology Rehabilitation, “S. Maugeri” Foundation, IRCCS, Scientific Institute of Veruno
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- Mezzani Alessandro
- Division of Cardiology Rehabilitation, “S. Maugeri” Foundation, IRCCS, Scientific Institute of Veruno
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- Piepoli Massimo
- UOC Cardiologia, G da Saliceto Hospital
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- Di Lenarda Andrea
- Cardiovascular Center, Health Authority no.°1 and University of Trieste
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- Iorio Annamaria
- Cardiovascular Department, Ospedali Riuniti and University of Trieste
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- Passino Claudio
- Gabriele Monasterio Foundation, CNR-Regione Toscana Scuola Superiore S. Anna
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- Magrì Damiano
- Department of Clinical and Molecular Medicine, Azienda Ospedaliera Sant’Andrea, “Sapienza” University of Roma
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- Masarone Daniele
- Cardiology SUN, Monaldi Hospital (Azienda dei Colli), Second University of Napoli
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- Battaia Elisa
- Section of Cardiology, Department of Medicine, University of Verona
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- Girola Davide
- Cardiologic Department “A. De Gasperis”, Cà Granda-A.O. Hospital Niguarda
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- Re Federica
- Cardiology Division, Cardiac Arrhythmia Center and Cardiomyopathies Unit, San Camillo-Forlanini Hospital
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- Cattadori Gaia
- Centro Cardiologico Monzino, IRCCS
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- Parati Gianfranco
- Department of Health Science, University of Milano Bicocca & Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano
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- Sinagra Gianfranco
- Cardiovascular Department, Ospedali Riuniti and University of Trieste
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- Villani Giovanni Quinto
- UOC Cardiologia, G da Saliceto Hospital
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- Limongelli Giuseppe
- Cardiology SUN, Monaldi Hospital (Azienda dei Colli), Second University of Napoli
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- Pacileo Giuseppe
- Cardiology SUN, Monaldi Hospital (Azienda dei Colli), Second University of Napoli
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- Guazzi Marco
- Heart Failure Unit, IRCCS Policlinico San Donato
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- Metra Marco
- Cardiology, Department of Medical and Surgical Specialities, Radiological Sciences, and Public Health, University of Brescia
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- Frigerio Maria
- Cardiologic Department “A. De Gasperis”, Cà Granda-A.O. Hospital Niguarda
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- Cicoira Mariantonietta
- Section of Cardiology, Department of Medicine, University of Verona
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- Minà Chiara
- ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies)
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- Malfatto Gabriella
- Department of Health Science, University of Milano Bicocca & Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano
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- Caravita Sergio
- Department of Health Science, University of Milano Bicocca & Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano
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- Bussotti Maurizio
- Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Institute of Milan
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- Salvioni Elisabetta
- Centro Cardiologico Monzino, IRCCS
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- Veglia Fabrizio
- Centro Cardiologico Monzino, IRCCS
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- Correale Michele
- Department of Cardiology, University of Foggia
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- Scardovi Angela B.
- Cardiology Division, Santo Spirito Hospital
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- Emdin Michele
- Gabriele Monasterio Foundation, CNR-Regione Toscana
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- Giannuzzi Pantaleo
- Division of Cardiology Rehabilitation, “S. Maugeri” Foundation, IRCCS, Scientific Institute of Veruno
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- Gargiulo Paola
- SDN Foundation, Institute of Diagnostic and Nuclear Development
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- Giovannardi Marta
- Centro Cardiologico Monzino, IRCCS
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- Perrone-Filardi Pasquale
- Department of Advanced Biomedical Sciences, “Federico II” University
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- Raimondo Rosa
- “S. Maugeri” Foundation, IRCCS, Institute of Tradate, Department of Medicine and Cardiorespiratory Rehabilitation, Unit of Cardiac Rehabilitation, Tradate
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- Ricci Roberto
- Cardiology Division, Santo Spirito Hospital
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- Paolillo Stefania
- Department of Advanced Biomedical Sciences, “Federico II” University
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- Farina Stefania
- Centro Cardiologico Monzino, IRCCS
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- Belardinelli Romualdo
- Cardiologia Riabilitativa, Azienda Ospedali Riuniti
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- Passantino Andrea
- Division of Cardiology, “S. Maugeri” Foundation, IRCCS, Institute of Cassano Murge
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- La Gioia Rocco
- Division of Cardiology, “S. Maugeri” Foundation, IRCCS, Institute of Cassano Murge
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Background:Chronic kidney disease is associated with sympathetic activation and muscle abnormalities, which may contribute to decreased exercise capacity. We investigated the correlation of renal function with peak exercise oxygen consumption (V̇O2) in heart failure (HF) patients.Methods and Results:We recruited 2,938 systolic HF patients who underwent clinical, laboratory, echocardiographic and cardiopulmonary exercise testing. The patients were stratified according to estimated glomerular filtration rate (eGFR). Mean follow-up was 3.7 years. The primary outcome was a composite of cardiovascular death and urgent heart transplantation at 3 years. On multivariable regression, eGFR was predictor of peakV̇O2(P<0.0001). Other predictors were age, sex, body mass index, HF etiology, NYHA class, atrial fibrillation, resting heart rate, B-type natriuretic peptide, hemoglobin, and treatment. After adjusting for significant covariates, the hazard ratio for primary outcome associated with peakV̇O2<12 ml·kg−1·min−1was 1.75 (95% confidence interval (CI): 1.06–2.91; P=0.0292) in patients with eGFR ≥60, 1.77 (0.87–3.61; P=0.1141) in those with eGFR of 45–59, and 2.72 (1.01–7.37; P=0.0489) in those with eGFR <45 ml·min−1·1.73 m−2. The area under the receiver-operating characteristic curve for peakV̇O2<12 ml·kg−1·min−1was 0.63 (95% CI: 0.54–0.71), 0.67 (0.56–0.78), and 0.57 (0.47–0.69), respectively. Testing for interaction was not significant.Conclusions:Renal dysfunction is correlated with peakV̇O2. A peakV̇O2cutoff of 12 ml·kg–1·min–1offers limited prognostic information in HF patients with more severely impaired renal function. (Circ J 2015; 79: 583–591)
収録刊行物
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- Circulation Journal
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Circulation Journal 79 (3), 583-591, 2015
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680083683840
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- NII論文ID
- 130004927090
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 026187045
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- PubMed
- 25746543
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可