A Case of Neuro-Sweet Disease Diagnosed from Skin Lesions

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  • 皮膚症状より診断しえた神経 Sweet 病

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Abstract

A 33-year-old man whose medical history included acute disseminated encephalomyelitis was admitted to our hospital with acute tonsillitis in February 2008 with high fever and diarrhea. Antibiotics and antivirals were not effective. Three days after hospitalization, his level of consciousness worsened and he was diagnosed with encephalitis. When he consulted a dermatologist, he had many erythematous eruptions with erosion on his face and his legs. Histopathologic examination of the erythema on the eyelid of the patient demonstrated dermal infiltration with numerous neutrophils. FLAIR MRI imaging showed high signal intensity. A final diagnosis of neuro-Sweet Disease was made by brain MRI and skin biopsy. After systemic administration of corticosteroids therapy, his tonsillitis and erythema improved, although slight fever remained. All his symptoms disappeared after starting colchicine. On HLA typing, B54 and Cw1 were positive. Careful attention should be paid to neurological symptoms when examining a patient with neuro-Sweet disease.Skin Research, 11: 197-201, 2012

Journal

  • Hifu no kagaku

    Hifu no kagaku 11 (3), 197-201, 2012

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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