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- 中野 元文
- Research Center, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- 八十川 伯朗
- Development Department, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- 諏訪 明之
- Research Center, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- 藤岡 伸祐
- Development Department, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- 古谷 敬
- Research Center, Research & Development Division, Nihon Nohyaku Co., Ltd.
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- 坂田 和之
- Research Center, Research & Development Division, Nihon Nohyaku Co., Ltd.
書誌事項
- タイトル別名
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- Mode of action of novel acaricide pyflubumide: Effects on the mitochondrial respiratory chain
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抄録
This study aimed to determine the mode of action of pyflubumide, a novel acaricide under development by Nihon Nohyaku Co., Ltd. Because of its structural similarity to succinate-dehydrogenase inhibitor (SDHI) fungicides, its ability to inhibit mitochondrial complex II was investigated. Pyflubumide exhibited low inhibitory activity on spider mite mitochondria; conversely, its deacylated metabolite (NH-form) showed high mitochondrial inhibitory activity. Pyflubumide was quickly metabolized to its NH-form in the homogenate of spider mites. These results suggest that pyflubumide is a prodrug and that the NH-form is active. Indeed, the NH-form of pyflubumide and the OH-form of cyenopyrafen, a complex II inhibitory acaricide, act on the same enzyme; a double-inhibitor titration assay showed that the binding sites on mitochondrial complex II and/or the manners of binding of these compounds exhibit clear differences. This finding suggests that these two acaricides should be classified into different groups in terms of their mode of action.
収録刊行物
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- 日本農薬学会誌(Journal of Pesticide Science)
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日本農薬学会誌(Journal of Pesticide Science) 40 (1), 19-24, 2015
日本農薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282680188339968
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- NII論文ID
- 130004939750
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- NII書誌ID
- AA11818622
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- ISSN
- 13490923
- 03851559
- 1348589X
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- NDL書誌ID
- 026393036
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可