Parasympathetic Reinnervation Accompanied by Improved Post-Exercise Heart Rate Recovery and Quality of Life in Heart Transplant Recipients
-
- Imamura Teruhiko
- Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo
-
- Kinugawa Koichiro
- Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo
-
- Okada Ikuko
- Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo
-
- Kato Naoko
- Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo
-
- Fujino Takeo
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
-
- Inaba Toshiro
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
-
- Maki Hisataka
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
-
- Hatano Masaru
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
-
- Kinoshita Osamu
- Department of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo
-
- Nawata Kan
- Department of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo
-
- Kyo Shunei
- Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo
-
- Ono Minoru
- Department of Cardiac Surgery, Graduate School of Medicine, The University of Tokyo
この論文をさがす
抄録
Although sympathetic reinnervation is accompanied by the improvement of exercise tolerability during the first years after heart transplantation (HTx), little is known about parasympathetic reinnervation and its clinical impact. We enrolled 21 recipients (40 ± 16 years, 71% male) who had received successive cardiopulmonary exercise testing at 6 months, and 1 and 2 years after HTx. Exercise parameters such as peak oxygen consumption or achieved maximum load remained unchanged, whereas recovery parameters including heart rate (HR) recovery during 2 minutes and the delay of peak HR, which are influenced by parasympathetic activity, improved significantly during post-HTx 2 years (P < 0.05 for both). HR variability was analysed at post-HTx 6 months in 18 recipients, and high frequency power, representing parasympathetic activity, was significantly associated with the 2 recovery parameters (P < 0.05 for all). We also assessed quality of life using the Minnesota Living with Heart Failure (HF) Questionnaire at post-HTx 6 months and 2 years in the same 18 recipients, and those with improved recovery parameters enjoyed a better HF-specific quality of life (P < 0.05 for both). In conclusion, parasympathetic reinnervation emerges along with improved post-exercise recovery ability of HR and quality of life during post-HTx 2 years.
収録刊行物
-
- International Heart Journal
-
International Heart Journal 56 (2), 180-185, 2015
一般社団法人 インターナショナル・ハート・ジャーナル刊行会