書誌事項
- タイトル別名
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- Development of Drug Identification System for Benzodiazepines and Their Metabolites Using GC-MS
- GC-MSによるベンゾジアゼピン系薬物および代謝物の一斉検索システム
- GC MS ニ ヨル ベンゾジアゼピンケイ ヤクブツ オヨビ タイシャブツ ノ イッセイ ケンサク システム
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抄録
A fully automated identification system for 35 benzodiazepines and their 29 metabolites was developed by gas chromatography-mass spectrometry (GC-MS) with a DB-5MS fused silica capillary column after trimethylsilyl (TMS) and trifluoroacetyl (TFA) derivatization, followed by registering both their retention times and mass spectra as the standard library data.<br>All the analytes except for rilmazafone and haloxazolam were detectable with and/or without TMS derivatization. TFA derivatization was found to be more effective in the more sensitive analysis of oxazolo-benzodiazepines except for flutazolam. Also, correction of their retention times by alkanes enabled to accurately identify on the different GC-MS systems with different lots of columns.<br>The present system allowed us to identify benzodiazepines and their metabolites in urine and blood more readily in a much shorter time, and it will be a powerful system for the analysis of benzodiazepines in the forensic chemistry and toxicology fields.
収録刊行物
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- 日本法科学技術学会誌
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日本法科学技術学会誌 11 (1), 53-75, 2006
日本法科学技術学会