Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test

• Inami Keiko

  Faculty of Pharmaceutical Sciences, Tokyo University of Science Kyoritsu University of Pharmacy

• Takada Masashi

  Kyoritsu University of Pharmacy

• Itoh Kei

  Kyoritsu University of Pharmacy

• Ishikawa Satoko

  Kyoritsu University of Pharmacy Faculty of Pharmacy, Keio University

• Mochizuki Masataka

  Faculty of Pharmaceutical Sciences, Tokyo University of Science Kyoritsu University of Pharmacy

書誌事項

タイトル別名

• Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against <i>N</i>-Alkyl-<i>N</i>-nitrosoureas-induced Mutagenicity Using the <i>umu</i> Test

抄録

Carcinogenic N-methyl-N-nitrosourea (MNU) has been reported to be formed in vivo and suspected to be a causative agent for human cancer. Therefore, for cancer chemoprevention it is important to find compounds which inhibit N-alkyl-N-nitrosoureas-induced mutagenicity. The inhibitory effect of plant extracts against MNU mutagenicity was evaluated using the umu test. Among thirty aqueous extracts, derived from medicinal plants, seventeen extracts inhibited N-alkyl-N-nitrosoureas-induced mutagenicity using Salmonella typhimurium TA1535/pSK1002. Nine aqueous extracts; Astragalus Root, Bupleurum Root, Cimicifuga Rhizome, Cnidium Rhizome, Glycyrrhiza, Paony Root, Polygonatum Rhizome, Poria Sclerotium, and Processed Ginger, moderately inhibited N-alkyl-N-nitrosoureas-induced mutagenicity (IC₅₀>7.0 mg/mL), and eight aqueous extracts; Cinnamon Bark, Cinnamon Twig, Dodder Seed, Malaytea Scurfpea Fruit, Phellodendron Bark, Prunella Spike, Scisandra Fruit, and Suberect spatholobus Stem strongly inhibited N-alkyl-N-nitrosoureas-induced mutagenicity (IC₅₀<7.0 mg/mL) in Salmonella typhimurium TA1535/pSK1002. An aqueous extract from Suberect spatholobus Stem showed the most potent antimutagenic effects against N-alkyl-N-nitrosoureas.<br>

収録刊行物

• Genes and Environment

  Genes and Environment 36 (2), 33-38, 2014

  日本環境変異原学会

キーワード

• <i>N</i>-nitrosourea
• <i>Suberect spatholobus Stem</i>

詳細情報

• CRID: 1390001205256894592
• NII論文ID: 130004943658
• NII書誌ID: AA1212552X
• DOI: 10.3123/jemsge.2014.003
• ISSN: 18807062
• ISSN: 18807046
• NDL書誌ID: 025478580
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025478580
• Web Site: https://search.jamas.or.jp/link/ui/2015049357
• 本文言語コード: en
• データソース種別:
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  • NDL
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可