Recent advances in tissue-engineered corneal regeneration

DOI 参考文献68件
  • Kim Eun Young
    Department of PolymerNano Science & Technology, Department of BIN Fusion Technology and Polymer BIN Fusion Research Center, Chonbuk National University, Jeonju, Korea
  • Song Jeong Eun
    Department of PolymerNano Science & Technology, Department of BIN Fusion Technology and Polymer BIN Fusion Research Center, Chonbuk National University, Jeonju, Korea
  • Park Chan Hum
    Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Gangwon, Korea
  • Joo Choun-Ki
    Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Gangnam St. Mary Hospital, Seoul, Korea
  • Khang Gilson
    Department of PolymerNano Science & Technology, Department of BIN Fusion Technology and Polymer BIN Fusion Research Center, Chonbuk National University, Jeonju, Korea

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There are many dystrophies related corneal endothelium resulting in edema, loss of transparency and blindness, finally. Currently, transplantation is only surgical treatment for patients with these corneal endothelial dystrophies, however, the limitation of transplantation is the absolute deficiency of donor cornea. Very recently, to overcome this issue of limited supply of donor cornea, regenerative medicine including stem cell therapy and tissue engineering has been widely attempted and success for human clinical trial.<BR>In this review, recent advances for the regeneration of corneal endothelial cell (CEnC) as (1)isolation and culture methods of CEnC for the somatic cell source, (2)stem cell source for CEnC as embryonic, induce pluripotent stem cell (iPS) and adult stem cell, (3)tissue engineering techniques as cell sheet engineering and development of scaffold materials and finally (4)the application of silk as a biomaterial for cornea by our laboratory have been introduced.

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