Epithelial regeneration by transplantation of cultured intestinal stem cells

• Nakamura Tetsuya

  Department of Advanced Therapeutics for GI Diseases, Tokyo Medical and Dental University, Tokyo, Japan

抄録

Research on intestinal epithelial stem cells has flourished in the last few years since their specific markers were identified. However, to exploit the potentials of those adult stem cells as a source for regenerative medicine, validation of the tissue regeneration capability of intestinal stem cells would be essential. We have recently shown that, by employing murine models of transplantation, cultured intestinal epithelial cells from the adult colon, fetal small intestine (SI), and adult SI are able to regenerate epithelia in vivo, preserving their stem cell properties. These data provide the evidence that multiple types of intestinal cells could be the source for the stem cell therapy for intestinal diseases in humans.

収録刊行物

• Inflammation and Regeneration

  Inflammation and Regeneration 35 (1), 019-022, 2015

  一般社団法人 日本炎症・再生医学会

キーワード

• intestinal stem cells
• regenerative medicine
• stem cell culture
• transplantation

詳細情報

• CRID: 1390001205256577920
• NII論文ID: 130004943879
• DOI: 10.2492/inflammregen.35.019
• ISSN: 18808190
• ISSN: 18809693
• Web Site: https://search.jamas.or.jp/link/ui/2016090832
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可