FFT analyses of fibrin networks: The effect of cadmium on the spatial periodicity

DOI
  • Sakemi Hiroyuki
    Laboratory for Molecular and Cellular Biology, Oita University of Nursing and Health Sciences
  • Nishimura Naoko
    Laboratory for Molecular and Cellular Biology, Oita University of Nursing and Health Sciences
  • Yamaguchi Akiko
    Laboratory for Molecular and Cellular Biology, Oita University of Nursing and Health Sciences
  • Takahashi Kei
    Laboratory for Molecular and Cellular Biology, Oita University of Nursing and Health Sciences

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Other Title
  • フィブリンネットワーク構造に見いだされる周期性に及ぼすカドミウムの影響

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Abstract

Our previous study6) demonstrated that cadmium allowed to form abnormal fibrin clusters having a lowest value of fractal dimension among those by the other ions such as calcium, magnesium and zinc. Thus, it strongly suggested that the in vivo function of thrombi was impaired by cadmium. To evaluate further this structural characteristic, we carried out FFT (fast Fourier transform) analyses of fibrin networks to ask how cadmium affected the structural periodicity. Here we report the power spectra (spatial fluctuations) of normal fibrin networks to compare the periodicity of those networks with abnormal ones. 1) To begin with FFT, all the images made by cellular automata such as randomly distributed dots, percolation clustering and gradient percolation had three fluctuation components of 1/f0, 1/f1/2 and 1/f. Cyclic space as well as fibrin networks formed in the presence of calcium, magnesium and zinc revealed another components of 1/f1/7 and 1/f1/5 in addition to the 1/f. 2) However, fibrin networks exposed to cadmium showed an additional 1/f1/7 component of low power density (LPD). 3) To confirm whether or not cadmium propagated this specific effect, we compared surface plots of power spectrum and maps of the spatial frequencies of normal networks by calcium with those of abnormal ones by cadmium. The results demonstrated that cadmium allowed producing the 1/f1/7 of LPD. 4) FFT analysis of a selected area other than the abnormal clusters affected by cadmium showed a normal fluctuation component 1/f1/7. Vice versa, FFT analysis of contaminated debris- like clusters other than the normal fibrin networks by calcium demonstrated a fluctuation component 1/f1/7 of LPD. 5) The enhanced contrast of those pictures by PhotoShop demonstrated that fibrous fibrin networks or non-fibrous clusters were observed, respectively. Thus, it is concluded that cadmium specifically produced the 1/f1/7 component of LPD when denatured fibrins clustered.

Journal

  • Structure and Function

    Structure and Function 8 (1), 3-11, 2009

    Co-medical Research Society of Structure and Function

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