動物特ニ畜牛ノ實驗的Trypanosoma病ニ於ケルWassermann氏並Sachs-Georgi氏反應ノ消長

赤澤 笹雄, 伊藤 定隆, 葛西 勝彌

doi:10.1292/jvms1922.7.54

The trypanosome employed for the present experiment, in all probability identical with T. evansi, is the strain isolated from a water-buffalo in Formosa. The animals, such as cattle, horses and rabbits, were inoculated with this trypanosome and their sera were examined weekly after isoculation for a long period by the Wassermann (Browning) and Sachs-Georgi tests. The results of both syphilis reactions obtained in these experimentally infected animals are summarized as follows: 1) Of 8 typically infected Korean calves, all showed uniformly a strikingly positive reaction in the Wassermann complement-fixation and Sachs-Georgi flocculation tests. The vacillation of reaction was noted in all cases and ran almost parallel in both tests (Tables I-IV). 2) The Wassermann reaction in the infected cattle occurs generally some 10 weeks after inoculation. The positive reaction so developed, however, continues for some period and disappears. If the patient takes a delayed course, such a positive attack is repeated at irregular intervals. In the positive reaction extended for a long duration, there is also observed a number of oscillations in the complement-fixing power. 3) The Sachs-Georgi reaction, as compared with the Wassermann, appears far earlier and turns positive, in general 1 week after inoculation. The duration of positive reaction here is decidedly longer than that of complement-fixation. In the positive Sachs-Georgi reaction when long continued, the fluctuation is also noted to certain degree, though not so distinctly as in case of the Wassermann. 4) Two Korean calves in the suspected latent infection yielded a slight and unsteady positive effect in the complement-fixation test, while they exhibited a continued positive reaction in the flocculation test (Nos. 5 and 6, Table III). Such a dissociation of 2 reactions, therefore, may probably ascertain that the tested cattle contracts a latent infection with the trypanosome. 5) If it is to diagnose the trypanosomal infection of cattle by either of the 2 syphilis tests, we prefer the Sachs-Georgi test rather to the Wassermann, on account of the reasons mentioned above. However, the systematically repeated studies of the reaction only permit us to trace the bovine trypanosomiasis in all cases. 6) The serum from normal cattle frequently showed the presence of reacting substances in the Wassermann test (13 in 50), but it is exceptional in the Sachs-Georgi test (1 in 50) (Tables V). The case reacted negatively in 2 tests may later exhibit a temporary positive turn, when the test is repeatedly carried on (Table VI). 7) In general the reaction of normal sera develops slightly and disappears after 1 or 2 weeks. This feature contrasts markedly with the high degree of complement-fixation and the long duration of flocculation elicited with sera from cases of active trypanosomiasis. 8) Contrary to the case of infected cattle, out of 9 Korean ponies infected with T. evansi, 4 seemed to react negatively and 3 weakly (Tables VII anp VIII), while one of the remaining 2 gave a strongly positive result in both reactions and the other in the flocculation only (Table IX). 9) A Korean pony inoculated with T. equiperdum reacted slightly in both tests (Table X). 10) One of 5 normal ponies, each being tested 2-7 times, showed a weakly positive effect once in respective syphilitic reactions (Table X). 11) Of 10 trypanosome-infected rabbits, 7 brought a decidedly positive result in both reactions, the other 3 reacting weakly. The 2 reactions both turn positive in about 3 weeks after inoculation and fluctuate nearly parallel with sera from the same individual (Table XI). 12) The serum from normal rabbits frequently reacts positively in one or both of 2 tests.

動物特ニ畜牛ノ實驗的<i>Trypanosoma</i>病ニ於ケルWassermann氏並Sachs-Georgi氏反應ノ消長

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