難治性腹水におけるVEGF Familyの検討

DOI

書誌事項

タイトル別名
  • Vascular endothelial growth factors in cirrhotic patients with refractory ascites

この論文をさがす

抄録

Based on the ability to induce vascular leakage and promote the accumulation of ascites, vascular endothelial growth factor (VEGF) -A is considered as a vascular permeability factor. VEGF-C and VEGF-D drive lymphangiogenesis, which can provide conduits for fluid to extravasate from leaky blood vessels. In order to evaluate whether these VEGF family members play a role in refractory ascites (RA), VEGF-A, VEGF-C, and VEGF-D levels were measured in the ascitic fluid of cirrhotic patients using enzyme-linked immunosorbent assay. We studied 24 cirrhotic patients; 12 had RA (group 1) and 12 had non-RA (group 2). Ascitic VEGF-A levels were significantly higher in group 1 than in group 2. Thus, the VEGF-A levels is useful in the discrimination between patients with and without RA. Moreover, a significant correlation was observed between ascitic fluid VEGF-C levels and urinary sodium excretions, a predictor of RA. These results suggest that ascitic VEGF-A levels may be helpful in the diagnosis of RA in cirrhotic patients. In addition, ascitic VEGF-C levels, in association with decreased urinary sodium excretion, may contribute to the prediction of development of RA.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ