Metabolism of organic selenometabolites in brassicaceae family plants

• KATAYAMA Ayane

  Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University, Japan

• OGIHARA Yurie

  Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University, Japan

• YAWATA Ayako

  Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University, Japan

• ANAN Yasumi

  Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University, Japan

• OGRA Yasumitsu

  Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University, Japan

抄録

Selenium (Se) is an essential trace element and is required in the form of selenocysteine (SeCys) as an active center of some enzymes such as glutathione peroxidase in animals. Contrary to animals, Se is an unessential element for plants because no enzymes requiring SeCys have been known in plants. However, it is reported that Se stimulates the plant growth indirectly, hence, Se is recognized as a useful element for plants. Animals ingest Se mainly as selenoamino acids such as selenomethionine (SeMet) and Se-methylselenocysteine (MeSeCys) via food chain, and excrete Se in urine as organic selenometabolites such as methyl-2-acetamido-2-deoxy-1-seleno-β-D-galactopyranoside (selenosugar, SeSug). The urinary selenometabolite may be absorbed directly by plants without the intervention by saprotrophs. Thus, in this study, we speculate that plants have specific mechanisms underlying the metabolism of organic selenometabolites from animals and plants to consider the environmental circulation of Se. Brassicaceae family plants known as Se-accumulators were exposed to SeSug, selenomethionine (SeMet) and Se-methylselenocysteine (MeSeCys). The chemical species of Se in the plants were determined by an HPLC-ICP-MS. An unknown Se metabolite and MeSeCys were detected in the roots of the plants exposed with SeSug, SeMet or MeSeCys. The unknown Se metabolite was identified as methylselenoglutathione (GSSeMe) by an ESI-MS-MS. Consequently, we propose a novel metabolic pathway of the organic selenometabolites in the plants, i.e., the organic selenometabolites are commonly metabolized to MeSeCys via GSSeMe.

収録刊行物

• 日本毒性学会学術年会

  日本毒性学会学術年会 39.2 (0), AP-26-, 2012

  日本毒性学会

詳細情報

• CRID: 1390001205546751872
• NII論文ID: 130005009184
• DOI: 10.14869/toxpt.39.2.0.ap-26.0
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可