Anti-androgenic effects of diethyl-o-phthalate on immature male sprague-dawley rats

• LI Xiao lin

  School of Public Health, Fudan University, China Shanghai Entry-Exit Inspection and Quarantine Bureau, China

• QIU Lu

  Shanghai Entry-Exit Inspection and Quarantine Bureau, China

• GUO Hong wei

  School of Public Health, Fudan University, China

• WANG Yan

  Shanghai Entry-Exit Inspection and Quarantine Bureau, China

• JIANG Jing

  Shanghai Entry-Exit Inspection and Quarantine Bureau, China

• LI Jian

  Shanghai Entry-Exit Inspection and Quarantine Bureau, China

• BIAN Li na

  Shanghai Entry-Exit Inspection and Quarantine Bureau, China

• ZHANG Li ting

  Shanghai Entry-Exit Inspection and Quarantine Bureau, China

抄録

Objectives: The aim of this study is to evaluate the anti-androgenic effects of Diethyl-O-phthalate in the reproductive development of immature male rats in vivo. Methods: Immature Sprague-Dawley rats were dosed daily with corn oil or Diethyl-O-phthalate ( 100, 200 or 500 mg/kg ) by gavage from postnatal day(PND) 12 and through PND 35 respectively, Flutamide and Testosterone propionate were used as control. Sex accessory tissues were weighed and anogenital distances (AGD) were measured. Plasma levels of Testosterone(T) and luteinizing hormone(LH) were also evaluated with ELISA kits. Results: The weights of seminal vesicle, ventral prostate, drosolateral prostate, lecator ani/bulbocavernosus (LABC) muscle and AGD distances decreased significantly in response to Diethyl-O-phthalate in a dose-dependent manner, but no significant in the other accessory sex tissues. Testosterone levels were significantly decreased in Diethyl-O-phthalate treated groups, whereas luteinizing hormone levels were not altered. Conclusion: our results demonstrated that Diethyl-O-phthalate shows toxicological effects on the male reproductive system in immature male Sprague-Dawley rats resulted from its anti-androgenic effects.

収録刊行物

• 日本毒性学会学術年会

  日本毒性学会学術年会 39.2 (0), AP-71-, 2012

  日本毒性学会

詳細情報

• CRID: 1390001205546516096
• NII論文ID: 130005009234
• DOI: 10.14869/toxpt.39.2.0.ap-71.0
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可