Recommended dietary allowance (RDA) of baby aloe powder (BAP) based on toxicological evaluation

• LIM Seong Kwang

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• CHO Myung Chan

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• KWAK Min Young

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• KIM Min Ji

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• NAM Yoon A

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• CHUNG Bu Young

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• KYUNG Minji

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• BANG Du Yeon

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• KWON Mi Jung

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• KIM Young Woo

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

• KWACK Seung Jun

  Department of Biochemistry and Health Science, College of Natural Sciences, Changwon National University, Korea

• KIM Hyung Sik

  College of Pharmacy, Pusan National University, Korea

• LEE Byung-Mu

  Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Korea

抄録

Aloe has been used for versatile herbal medications and nutraceuticals throughout the history. However, little is known about the toxicology of aloe and it is of importance to determine a daily intake level to ensure its safety. To examine recommended dietary allowances (RDA) of baby aloe powder (BAP), Sprague-Dawley (SD) rats were orally treated with for 4-weeks at four different concentrations (0, 0.125, 0.5, 2 g/kg body weight (bw)). In this study, neither significant nor dose-dependent effects of BAP were observed in biochemical/hematological analysis, urinalysis, clinical signs, body weight, and food and water consumption. Some biomarkers did change compared with those of control but all of them were in their reference ranges. Based on the results we obtained, the no-observed-adverse-effect level (NOAEL) of the BAP was estimated to be 2 g/kg bw in male SD rats and 2 g/kg bw in female SD rats. Therefore, RDA or ADImax was ≥6.67 mg/kg bw/d [(2000 mg/kg bw/d) ÷ (100 for safety factor) × (3 for modifying factor)], or ≥400 mg for a 60-kg adult. Collectively, these data suggest that the baby aloe powder (BAP) used for this study did not cause any noticeable subacute toxic effects and could be used for nutraceuticals and other applications at concentration ≥400 mg for a 60-kg adult. <br>Key words: Baby aloe powder (BAP), recommended dietary allowances (RDA), safety, no-observed-effect level (NOAEL).

収録刊行物

• 日本毒性学会学術年会

  日本毒性学会学術年会 39.2 (0), AP-9-, 2012

  日本毒性学会

詳細情報

• CRID: 1390282680523234432
• NII論文ID: 130005009254
• DOI: 10.14869/toxpt.39.2.0.ap-9.0
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可