Design and Preparation of Ultra-Fine Drug by using a Supercritical Carbon Dioxide

• Nakagawa Yasuko

  Graduate School of Chemical Engineering, Osaka Prefecture University, Japan

• Watano Satoru

  Graduate School of Chemical Engineering, Osaka Prefecture University, Japan

• Iwamoto Daisuke

  Nara Machinery Co., Ltd., Japan

• Ichiki Azusa

  Nara Machinery Co., Ltd., Japan

• Hamada Kenji

  Nara Machinery Co., Ltd., Japan

抄録

Sub-micron and micron ranged drugs have wide applications such as inhalation therapy and cancer remedy. In this study, ultra-fine particles of adhesive active ingredient drug have been designed and prepared by using a supercritical carbon dioxide. The effects of operating parameters such as nozzle diameter, fluid temperature and pressure on the size distribution of the products were investigated. The optimum operating parameters for producing ultra-fine drug were determined experimentally. By means of a novel spray nozzle, production of film coated ultra-fine particles was also attempted. Sustained release property of the coated particles was evaluated. In addition, an effective particle collecting system was developed and its validity was investigated.

収録刊行物

• アジア・太平洋化学工学会議発表論文要旨集

  アジア・太平洋化学工学会議発表論文要旨集 2004 (0), 579-579, 2004

  公益社団法人 化学工学会

キーワード

• Supercritical CO<SUB>2</SUB>
• coating
• ultra fine particles
• effective collecting system

詳細情報

• CRID: 1390001205727503232
• NII論文ID: 130005052639
• DOI: 10.11491/apcche.2004.0.579.0
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可