Surface Structure Control of Gelatin Films using Micropit Array as a Mold

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抄録

Gelatin films are used in various fields such as an ideal delivery system for a wide range of medicine, food supplements in convenient and stable form, and a reasonably good stabilizer for various enzymes. Precision control of the surface structure of gelatin films will create new possibilities to the applications. We developed the micropit array, which has uniform quadrangular or circular pits with side length or diameters from 25 to 400µm and depth from 10 to 80 µm as a three dimensional structure. We attempted to use the micropit arrays as a mold in order to control the surface structures of gelatin films. Peeling gelatin cast off from a micropit array, gelatin film was obtained. The uniform cylindrical and cuboidal structures on the surface, which replicated the micropit array, were observed by scanning electron microscope. From these results, the precision control of the surface structure of gelatin films was confirmed to be possible. Analysis on release rate of fluorescein isothiocyanate bovine serum albumin (FITC-BSA) from gelatin films showed that more FITC-BSA was released from the films with cylinders on the surfaces compared with the film with smooth surface. In addition, the release rate of FITC-BSA from the surface with cylinders with diameter 50 µm was greater than that from the surface with cylinders with diameter 400 µm. The results were probably due to difference in the specific surface area of the films. These results imply that precisely designed microstructures on the gelatin surface by micropit array will enable us to control the release rates of pharmaceuticals in gelatin films.

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詳細情報 詳細情報について

  • CRID
    1390001205732412672
  • NII論文ID
    130005052997
  • DOI
    10.11491/apcche.2004.0.900.0
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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