Anti-inflammatory activities of fractions from Geranium nepalense and related polyphenols
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- Lu Chunhua
- Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
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- Li Yaoyao
- Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
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- Li Liji
- Kunming Institute of Medical Sciences
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- Liang Lanying
- Chinese Medicine Hospital of Yuncheng County
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- Shen Yuemao
- Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
書誌事項
- タイトル別名
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- Anti-inflammatory activities of fractions from <i>Geranium nepalense </i>and related polyphenols
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抄録
Geranium nepalense Sweet is a common Chinese herbal medicine and has been used as influenza, dysentery, antiphlogistic and analgesic tonic, hemostatic, stomachic, and antidiabetic drugs. The anti-inflammatory effects of G. nepalense on tetradecanoyl phorbol acetate (TPA)-induced mouse ear edema were studied in this work. The results showed that ethyl acetate fraction of the water extract of G. nepalense possessed significant activity at 2.5 g/kg (p < 0.01) with aspirin as a positive control (0.6 g/kg). Six polyphenolic compounds, including three flavonoids, i.e. kaempferol, kaempferol-7-O-β-D-glucopyranoside, and quercetin-7-O-α-rhamnopyranoside, and two tannins, i.e. pyrogallol and gallic acid, and one lignin, i.e. epipinoresinol, were isolated and characterized from ethyl acetate fraction. The isolation of polyphenols provides a clue for beneficial effects of G. nepalense in the demonstrated anti-inflammatory activity.
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 6 (4), 194-197, 2012
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