Ion-exchange complex of famotidine: sustained release and taste masking approach of stable liquid dosage form
-
- Aman Reham Mokhtar
- Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University
-
- Meshali Mahasen Mohamed
- Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University
-
- Abdelghani Galal Mahmoud
- Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University
この論文をさがす
抄録
A stable controlled release resinate-complex for the highly bitter taste famotidine (FAM) was developed to allow once-daily administration and improve patient compliance especially in pediatric and geriatric medicine. The drug-resinate complexes were prepared in different drug to resin (Amberlite IRP-69) ratios by weight (1:1, 1:2, 1:3, 1:4, 1:5 and 1:6). The optimized drug-resinate complex resulted from 1:6 drug to resin ratio experienced maximum drug loading and sustained release property. Hence, it was subjected to physicochemical characterizations by differential scanning colorimetry (DSC), x-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). The optimized complex was further dispensed in the prepared syrup and the suspension was subjected to accelerated stability study, as mentioned in the International Conference on Harmonization (ICH) guidelines. Furthermore, the gustatory properties of the complex were evaluated on humans. The syrup complied successfully with ICH guidelines and sufficiently alleviated the bitterness of famotidine.
収録刊行物
-
- Drug Discoveries & Therapeutics
-
Drug Discoveries & Therapeutics 8 (6), 268-275, 2014
特定非営利活動法人 バイオ&ソーシャル・サイエンス推進国際研究交流会