書誌事項
- タイトル別名
-
- Fundamental assessment of chemiluminescent enzyme immunoassay measurement reagent “BNP-JP: Architect”and the relationship between plasma concentrations of brain natriuretic peptide (BNP) and parameters of echocardiography
この論文をさがす
抄録
We examined the fundamental performance of a reagent “BNP-JP Architect” and the relationship between the concentrations of brain natriuretic peptide (BNP) and the parameters of echocardiography. BNP-JP Architect had satisfactory performance, except for the effect of hemolysis. The relationship between plasma BNP level and the parameters of echocardiography was evaluated in 120 patients with sinus rhythm (mean age 69 ± 13 years old, 70 men, 50 women). Plasma BNP level correlated with left atrial dimension (LAD) (r = 0.39, p < 0.01), left ventricular end-diastolic dimension (r = 0.22, p < 0.05), ejection fraction (EF) (r = –0.40, p < 0.01), and ratio of the peak velocity of transmitral flow during early diastole to the peak myocardial velocity during early diastole at septal annulus (E/e') (r = 0.53, p < 0.01). In multivariate linear regression analysis, EF (p = 0.04) and E/e' (p < 0.01) were independent determinants of plasma BNP level. Patients with decreased renal function (estimated glomerular filtration ratio (eGFR) <60 ml/min/1.73 m2) were older (p < 0.01) and had higher LAD (p < 0.05), E/e' (p = 0.01), and plasma BNP level (p < 0.01) than patients with preserved renal function (eGFR≧60 ml/min/1.73 m2). Although renal function should be considered when interpreting plasma BNP level, the plasma BNP level measured by BNP-JP Architect can be used as a surrogate marker of left ventricular (LV) systolic function and LV filling pressure and provide useful information for the diagnosis of heart failure.
収録刊行物
-
- 医学検査
-
医学検査 63 (1), 29-35, 2014
一般社団法人 日本臨床衛生検査技師会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205742273920
-
- NII論文ID
- 130005057024
-
- ISSN
- 21885346
- 09158669
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可