Tandemly Repeated Peptide for Cancer-specific Gene Carrier Prepared by Native Chemical Ligation

• Daiki Funamoto

  Graduate School of System Life Sciences, Kyushu University

• Daisuke Asai

  Department of Microbiology, St. Marianna University School of Medicine

• Chan Woo Kim

  Graduate School of System Life Sciences, Kyushu University

• Yuta Nakamura

  Graduate School of System Life Sciences, Kyushu University

• Eun Kyung Lee

  Graduate School of System Life Sciences, Kyushu University

• Takanobu Nobori

  Graduate School of System Life Sciences, Kyushu University

• Takuro Niidome

  Graduate School of System Life Sciences, Kyushu University

• Takeshi Mori

  Graduate School of System Life Sciences, Kyushu University

• Yoshiki Katayama

  Graduate School of System Life Sciences, Kyushu University

抄録

We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues.

収録刊行物

• Chemistry Letters

  Chemistry Letters 44 (4), 474-476, 2015-01-10

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360002219105635200
• NII論文ID: 130005062141
• DOI: 10.1246/cl.141121
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/44/4/474/55642816/cl.141121.pdf
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