Differential effects of strong and regular statins on the clinical outcome of patients with chronic kidney disease following coronary stent implantation—The Kumamoto intervention conference study (KICS) registry
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- Ishii Masanobu
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Hokimoto Seiji
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Akasaka Tomonori
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Fujimoto Kazuteru
- National Hospital Organization Kumamoto Medical Center
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- Miyao Yuji
- National Hospital Organization Kumamoto Medical Center
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- Kaikita Koichi
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Oshima Shuichi
- Division of Cardiology, Kumamoto Central Hospital
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- Nakao Koichi
- Cardiovascular Center, Kumamoto Saiseikai Hospital
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- Shimomura Hideki
- Division of Cardiology, Fukuoka Tokushukai Hospital
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- Tsunoda Ryusuke
- Kumamoto Red Cross Hospital
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- Hirose Toyoki
- Division of Cardiology, Minamata City Hospital and Medical Center
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- Kajiwara Ichiro
- Division of Arao City Hospital
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- Matsumura Toshiyuki
- Division of Kumamoto Rosai Hospital
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- Nakamura Natsuki
- Division of Shinbeppu Hospital
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- Yamamoto Nobuyasu
- Miyazaki Prefectural Nobeoka Hospital
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- Koide Shunichi
- Division of Health Insurance Yatsushiro General Hospital
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- Oka Hideki
- Division of Health Insurance Hitoyoshi General Hospital
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- Morikami Yasuhiro
- Division of Kumamoto City Hospital
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- Sakaino Naritsugu
- Division of Amakusa Regional Medical Center
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- Matsui Kunihiko
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Ogawa Hisao
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
書誌事項
- タイトル別名
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- Differential Effects of Strong and Regular Statins on the Clinical Outcome of Patients With Chronic Kidney Disease Following Coronary Stent Implantation – The Kumamoto Intervention Conference Study (KICS) Registry –
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Background:The aim of this study was to examine the effects of different statins on the clinical outcomes of Japanese patients with coronary stent implants.Methods and Results:This study included 5,801 consecutive patients (males, 4,160; age, 69.7±11.1 years, mean±SD) who underwent stent implantation between April 2008 and March 2011. They were treated with a strong statin (n=3,042, 52%, atorvastatin, pitavastatin, or rosuvastatin), a regular statin (n=1,082, 19%, pravastatin, simvastatin, or fluvastatin) or no statin (n=1,677, 29%). The patients with chronic kidney disease (CKD) were divided into mild-to-moderate CKD (30≤eGFR<60, n=1,956) and severe CKD (eGFR <30, n=559). Primary endpoints included cardiovascular death and nonfatal myocardial infarction, including stent thrombosis and ischemic stroke. The clinical outcome for the primary endpoint in mild-to-moderate CKD patients treated with a strong statin (hazard ratio 0.50, 95% confidence interval 0.31–0.81; P=0.005) was significantly lower than in those on no statins, but that in the patients treated with a regular statin was not (P=0.160). The clinical outcome for the primary endpoint in severe CKD patients treated with a strong or regular statin was no different than not being on statin therapy (P=0.446, P=0.194, respectively).Conclusions:In patients with mild-to-moderate CKD, only strong statins were associated with lower risk compared with no statin, but regular statins were not. It is possible that taking a strong statin from the early stage of CKD is useful for suppression of cardiovascular events. (Circ J 2015; 79: 1115–1124)
収録刊行物
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- Circulation Journal
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Circulation Journal 79 (5), 1115-1124, 2015
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205109224832
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- NII論文ID
- 130005066265
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 026342764
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- PubMed
- 25739954
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可