The Influence of Biodegradable Gemini Surfactants, N,N’-bis(1-Decyloxy-1-Oxopronan-2-yl)-N,N,N’,N’ Tetramethylpropane-1,3-Diammonium Dibromide and N,N’-bis(1-Dodecyloxy-1-Oxopronan-2-yl) N,N,N’,N’-Tetramethylethane-1,2-Diammonium Dibromide, on Fungal Biofilm and Adhesion
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- Obłąk Ewa
- Institute of Genetics and Microbiology, University of Wroclaw
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- Piecuch Agata
- Institute of Genetics and Microbiology, University of Wroclaw
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- Dworniczek Ewa
- Department of Microbiology, Wroclaw Medical University
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- Olejniczak Teresa
- The Faculty of Food Science, Department of Chemistry, Wrocław University of Environmental and Life Sciences
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A group of biodegradable alanine-derived gemini quaternary ammonium salts (bromides and chlorides) with various alkyl chains and spacer lengths was tested for anti-adhesive and anti-biofilm activity. The strongest antifungal activity was exhibited by bromides with 10 and 12 carbon atoms within hydrophobic chains (N,N’-bis(1-decyloxy-1-oxopronan-2-yl)-N,N,N’,N’-tetramethylpropane-1,3-diammonium dibromide and N,N’-bis(1-dodecyloxy-1-oxopronan-2-yl)-N,N,N’,N’-tetramethylethane-1,2-diammonium dibromide). It was also demonstrated that these gemini surfactants enhanced the sensitivity of Candida albicans to azoles (itraconazole and fluconazole) and polyenes (amphotericin B and nystatine). Gemini quaternary ammonium salts effectively inhibited fungal cell adhesion to polystyrene and silicone surface. These compounds reduced C. albicans filamentation and eradicated C. albicans and Rhodotorula mucilaginosa biofilms, as it was shown in crystal violet and fluorescent staining. None of the tested compounds were cytotoxic against yeast mitochondrial metabolism.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 64 (5), 527-537, 2015
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204090662528
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- NII論文ID
- 130005067208
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 026335870
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- PubMed
- 25843277
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可