Changes in energy metabolism after induction therapy in patients with severe or moderate ulcerative colitis

• Inoue Mai

  Division of Clinical Nutrition, Shiga University of Medical Science

• Sasaki Masaya

  Division of Clinical Nutrition, Shiga University of Medical Science

• Takaoka Azusa

  Division of Clinical Nutrition, Shiga University of Medical Science

• Kurihara Mika

  Division of Clinical Nutrition, Shiga University of Medical Science

• Iwakawa Hiromi

  Division of Clinical Nutrition, Shiga University of Medical Science

• Bamba Shigeki

  Department of Gastroenterology, Shiga University of Medical Science

• Ban Hiromitsu

  Division of Endoscopy, Shiga University of Medical Science

• Andoh Akira

  Department of Gastroenterology, Shiga University of Medical Science

抄録

We investigated the changes in energy expenditure during induction therapy in patients with severe or moderate ulcerative colitis. Thirteen patients (10 men, 3 women; mean age, 36.5 years) with ulcerative colitis admitted to the Shiga University Hospital were enrolled in this study. We measured the resting energy expenditure and respiratory quotients of these patients before and after induction therapy with indirect calorimetry. We analyzed the changes of nutritional status and serum inflammatory cytokine levels and also evaluated the relationship between energy metabolism and disease activity by using the Seo index and Lichtiger index. The resting energy expenditure was 26.3 ± 3.8 kcal/kg/day in the active stage and significantly decreased to 23.5 ± 2.4 kcal/kg/day after induction therapy (p<0.01). The resting energy expenditure changed in parallel with the disease activity index and C-reactive protein and inflammatory cytokine levels. The respiratory quotient significantly increased after induction therapy. Thus, moderate to severe ulcerative colitis patients had a hyper-metabolic status, and the energy metabolism of these patients significantly changed after induction therapy. Therefore, we recommend that nutritional management with 30–34 kcal/kg/day (calculated as measured resting energy expenditure × activity factor, 1.3) may be optimal for hospitalized ulcerative colitis patients.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 56 (3), 215-219, 2015

  一般社団法人　日本酸化ストレス学会

キーワード

• ulcerative colitis
• indirect calorimetry
• energy expenditure
• respiratory quotient
• induction therapy

詳細情報

• CRID: 1390001204670734080
• NII論文ID: 130005068185
• DOI: 10.3164/jcbn.14-100
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://search.jamas.or.jp/link/ui/2016045679
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可