Isoniazid-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Presenting as Acute Eosinophilic Myocarditis
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- Zhang Sai-Nan
- Department of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, China
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- He Qiu-Xiang
- Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, China
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- Yang Nai-Bin
- Department of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, China
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- Ni Shun-Lan
- Department of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, China
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- Lu Ming-Qin
- Department of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, China
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抄録
It has been reported that hypereosinophilic syndrome may be induced by antituberculosis drugs. We herein report the case of a 43-year-old man who had been on antituberculosis drugs for two months to treat tuberculous meningitis. During therapy, he suffered from drug rash with eosinophilia and systemic symptoms (DRESS) presenting as acute eosinophilic myocarditis, as confirmed on a histopathologic examination. According to the patient's medication history, clinical features and accessory examination findings, the eosinophilic myocarditis was thought to be possibly induced by isoniazid. Although further investigations are needed to confirm causality, isoniazid may be added to the list of drugs with the potential to cause DRESS syndrome.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 54 (10), 1227-1230, 2015
一般社団法人 日本内科学会