C35 is overexpressed in colorectal cancer and is associated tumor invasion and metastasis

DOI 被引用文献3件 参考文献12件
  • Dong Xuan
    Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases School of Medicine and Life Sciences, Ji'nan University, Shandong Academy of Medicine Sciences
  • Huang Yong
    Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
  • Kong Lingbin
    Ji'ning Medical University
  • Li Jin
    Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
  • Kou Jingxuan
    Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
  • Yin Lixin
    Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
  • Yang Jingyu
    Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases

この論文をさがす

抄録

The aim of this study was to investigate the expression of C35, an oncogene previously found in breast and prostate cancers, and its clinicopathological significance in colorectal cancer (CRC). Qualitative and quantitative detection of C35 mRNA expression was performed using reverse transcription-PCR (RT-PCR) and real-time PCR. C35 protein expression was determined using immunohistochemistry. C35 mRNA was detected in none of 10 normal colorectal tissue samples, 55 of 65 (84.6%) CRC tissue samples, and 43 of 55 (78.2%) adjacent non-cancerous tissue samples. In addition, the level of C35 mRNA in CRC tissue samples was markedly higher than that in tumor adjacent non-cancerous tissue samples. C35 protein expression was detected in 58 of 80 (72.5%) CRC tissue samples and was closely associated with tumor serosal invasion, lymphnode metastasis, and an advanced Dukes stage. These results suggest that C35 might serve as a biomarker or therapeutic target for management of CRC.

収録刊行物

  • BioScience Trends

    BioScience Trends 9 (2), 117-121, 2015

    特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会

被引用文献 (3)*注記

もっと見る

参考文献 (12)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ