Seroprevalence of Yellow Fever Virus in Selected Health Facilities in Western Kenya from 2010 to 2012

• Kwallah Allan ole

  Institute of Tropical Medicine and Infectious Diseases (ITROMID), Jomo Kenyatta University of Agriculture and Technology (JKUAT) Centre for Infectious and Parasitic Diseases Control Research (CIPDCR), Kenya Medical Research Institute (KEMRI) Production Department, Kenya Medical Research Institute (KEMRI)

• Inoue Shingo

  Department of Virology, Institute of Tropical Medicine, Nagasaki University

• Thairu-Muigai Anne Wangari

  Institute of Tropical Medicine and Infectious Diseases (ITROMID), Jomo Kenyatta University of Agriculture and Technology (JKUAT)

• Kuttoh Nancy

  Centre for Infectious and Parasitic Diseases Control Research (CIPDCR), Kenya Medical Research Institute (KEMRI)

• Morita Kouichi

  Department of Virology, Institute of Tropical Medicine, Nagasaki University

• Mwau Matilu

  Centre for Infectious and Parasitic Diseases Control Research (CIPDCR), Kenya Medical Research Institute (KEMRI)

抄録

Yellow fever (YF), which is caused by a mosquito-borne virus, is an important viral hemorrhagic fever endemic in equatorial Africa and South America. Yellow fever virus (YFV) is the prototype of the family Flaviviridae and genus Flavivirus. The aim of this study was to determine the seroprevalence of YFV in selected health facilities in Western Kenya during the period 2010–2012. A total of 469 serum samples from febrile patients were tested for YFV antibodies using in-house IgM-capture ELISA, in-house indirect IgG ELISA, and 50% focus reduction neutralization test (FRNT₅₀). The present study did not identify any IgM ELISA-positive cases, indicating absence of recent YFV infection in the area. Twenty-eight samples (6%) tested positive for YFV IgG, because of either YFV vaccination or past exposure to various flaviviruses including YFV. Five cases were confirmed by FRNT₅₀; of these, 4 were either vaccination or natural infection during the YF outbreak in 1992–1993 or another period and 1 case was confirmed as a West Nile virus infection. Domestication and routine performance of arboviral differential diagnosis will help to address the phenomenon of pyrexia of unknown origin, contribute to arboviral research in developing countries, and enhance regular surveillance.

収録刊行物

• Japanese Journal of Infectious Diseases

  Japanese Journal of Infectious Diseases 68 (3), 230-234, 2015

  国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

キーワード

• YFV
• FRNT
• Kenya
• IgM ELISA
• IgG ELISA

詳細情報

• CRID: 1390282681216804224
• NII論文ID: 130005070794
• NII書誌ID: AA1132885X
• DOI: 10.7883/yoken.jjid.2014.288
• ISSN: 18842836
• ISSN: 13446304
• HANDLE: 10069/35491
• NDL書誌ID: 026408182
• PubMed: 25672346
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/4363
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026408182
• Web Site: https://search.jamas.or.jp/link/ui/2016110768
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可